Alderbio Holdings LLC

Dan Scott Allison

John A Latham

Leon F Garcia-Martinez

Benjamin H Dutzar

Brian Robert Kovacevich

Ethan Wayne Ojala

Patricia Dianne McNeill

Katie Olson Anderson

Pei Fan

Jens J Billgren

Erica Ann Stewart

Andrew Lawrence Feldhaus

Danielle Mitchell

Corinne C Akatsuka

The present invention is directed to antibodies and fragments thereof having binding specificity for PCSK9. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V, Vand CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-PCSK9 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-PCSK9 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-PCSK9 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with PCSK9.

Anti-PCSK9 antibodies and use thereof

Growing community of inventors

Lake Forrest Park, WA, United States of America

Dan Scott Allison