Roche Diagnostics Operations, Inc.

Roche Operations Ltd.

Boehringer Mannheim Gmbh

Roche Diagnostics Gmbh

Roche Diabetes Care, Inc.

F. Hoffmann-la Roche Ag

Dan Mosoiu

Michael Fritz

David W Burke

Michael Marquant

Christopher Douglas Wilsey

Wolfgang-Reinhold Knappe

Peter Vogel

Detlef Thym

Udo Zapf

Chris Wilsey

Joachim Hoenes

Carina Horn

Franz Wittmann

Hans Gotschel

Winfried Plesch

A test strip having a small sample-receiving chamber on the order of less than 1 microliter. The inventive test strip includes a reagent layer that extends across the width of the test strip and also extends to the sample-receiving end, such that the edges of the reagent layer are aligned with the side and dose receiving edges of the test strip. The hydrophilic reagent extending to the dosing edge of the strip promotes wicking of the sample into the test strip. The end and side edges of the reagent layer are preferably formed as part of a cutting process that forms individual test strips from a larger web, which results in a smooth and thin reagent layer with a uniform thickness, substantially covering the entire floor of the sample-receiving chamber. The inventive mass production process helps improve the reproducibility of the quantity, location, thickness and other properties of the reagent layer, which in turn improves the accuracy of the test result.

Reagent stripe for test strip

The present invention concerns a reagent coating mass which can be used in slot-die-coating of flat support materials in the manufacturing processes of test strips. Advantageously, the reagent mass of the invention exhibits certain superior rheological properties such as viscosity, surface tension and thixotropy. The reagent mass is preferably used to coat thin, narrow and homogeneous stripes of reagent material onto flat web material.

Method and reagent for producing narrow, homogenous reagent strips

Method and reagent for producing narrow, homogenous reagent stripes

The invention concerns test elements and methods for the optical detection of an analyte in a sample. The test element includes a support having at least one transparent portion, and a one-layer film positioned on the support. The film has a thickness when dry of less than about 10 &#x3bc;m. The method includes contacting the sample with the test element and determining the analyte concentration in the sample.

Test element with a one layer reaction film

Functional layers of high precision, process for their production and test strips containing these functional layers

A test carrier for the determination of ions containing a test layer which has a liquid-resistant, organic phase which contains a hydrophobic polymer in a homogeneous mixture with a hydrophobic, organic liquid of low volatility and an ionophore, as well as a substance which changes its colour in the presence of the ion to be determined. The test carrier is characterized in that the test layer contains particles with an oil number of 80-200 and the ionophore is homogeneously dispersed in the hydrophobic, organic phase. A second test layer contains a buffer capable of maintaining the pH therein at a value of between 5-10.

Test carrier for the determination of ions

Method for the manufacture of a self-supporting test field material

The invention concerns a test carrier for the determination of ions containing a test layer which has a liquid-resistant, organic phase which contains a hydrophobic polymer in a homogeneous mixture with a hydrophobic, organic liquid of low volatility and an ionophore, as well as a substance which changes its colour in the presence of the ion to be determined. The test carrier is characterized in that the test layer contains particles with an oil number of 80-200 and the ionophore is homogeneously dispersed in the hydrophobic, organic phase.

Growing community of inventors

Limburgerhof, Germany

Dan Mosoiu