Algenol Biotech LLC

Algenol Biofuels, Inc.

Humboldt-universitaet Zu Berlin

Cyano Biotech Gmbh

Humboldt-Universität Zu Berlin

Dan Kramer

Heike Enke

Kerstin Baier

Alexandra Friedrich

Ulf Dühring

Kui Wang

Tuo Shi

Frank Uliczka

Irina Piven

Masami Inaba

Karl Ziegler

John Robert Coleman

R Paul Woods

Christine Oesterhelt

Ulf Duhring

Ulf Dehring

Ulf Duehring

Craig R Smith

Marianne Grundel

Wolfgang Lockau

Ulf DÜHRING

A genetically enhanced cyanobacterial host cell,sp. ABICyanoI, is disclosed. The enhancedsp. ABICyanoI produces a compound or compounds of interest.

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This invention provides a method for the prolonged production of ethanol using a metabolically enhanced cyanobacterium.

Metabolically enhanced cyanobacterium with sequentially inducible production genes for the production of a first chemical compound

The invention provides novel compositions of matter for the production of ethanol from carbon dioxide and water. Particularly, the invention provides photoautotrophic organisms having a first and second genetic modification, wherein the first genetic modification improves the ethanol production from organisms having the second genetic modification.

Genetically modified cyanobacteria for the production of ethanol

This invention provides a metabolically enhanced cyanobacterium for the production of a chemical compound of interest, having at least two first production genes encoding first biocatalysts for the production of the first chemical compound. One of the two first production genes is under the transcriptional control of a first promoter for the first production gene, whereas the other of the two first production genes is under the transcriptional control of a second promoter for the first production gene. The first promoter and second promoter are separately inducible under different conditions and the at least two first biocatalysts catalyze the same chemical reaction. Metabolically enhanced cyanobacteria according to the present invention allow prolonged production of first chemical compounds. Further provisions of the present invention include, inter alia, a method for producing the metabolically enhanced cyanobacterium and a method for producing a first chemical compound by culturing the metabolically enhanced cyanobacterium.

A cyanobacterial host cell,sp., that harbors at least one recombinant gene for the production of a chemical compounds is provided, as well as vectors derived from an endogenous plasmid isolated from the cell.

A genetically enhanced cyanobacterial host cell,sp. ABICyano1, is disclosed. The enhancedsp. ABICyano1 produces a compound or compounds of interest.

The present invention discloses genetically-modified cyanobacteria with ethanol-production capabilities enhanced over the currently-reported art, and methods of making such cyanobacteria. The invention provides a genetically modified photoautotrophic, ethanol producing host cell comprising an overexpressed pyruvate decarboxylase enzyme converting pyruvate to acetaldehyde and an overexpressed Zn2+ dependent alcohol dehydrogenase enzyme converting acetaldehyde to ethanol.

Selection of ADH in genetically modified cyanobacteria for the production of ethanol

The invention provides for nucleic acid molecules enabling the synthesis of microginin and microginin analogues. The invention also provides for methods for identifying microginins as well creating microginins which may not be found in nature.

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Berlin, Germany

Dan Kramer