Life Technologies Corporation

Medtronic Minimed, Inc.

Dan Kline

John Dixon

Ian Walton

Achim Karger

Robert L Cobene

Alexander V Dukhovny

Adam Sannicandro

Sheldon B Moberg

Afshin Bazargan

Kevin Lee Bokelman

Steve Masterson

Michael Simon

Alexander Khorlin

Robert Cobene

In one aspect, a biological sequencing device comprising a cartridge configured to be removed from the instrument is disclosed. In various embodiments the cartridge can include one or more capillaries suitable for capillary electrophoresis, a reservoir and a pump. In various embodiments the reservoir can contain a separation matrix. In various embodiments the pump can load a capillary with separation matrix. In another aspect the biological sequencing device can include one or more capillaries and an integrated valve assembly. In various embodiments the integrated valve assembly can provide a polymer to the one or more capillaries.

Apparatuses, systems and methods for sequencing using capillary electrophoresis

The present disclosure relates, in some embodiments, to an apparatus for conducting a capillary electrophoresis assay. The apparatus can comprise a capillary array comprising an anode end and a cathode end, the capillary array provided in a housing further comprising a reservoir configured to house a separation medium and an anode buffer. The system can also comprise an injection mechanism configured to deliver sample to the cathode end of the capillary array, and a temperature control zone, wherein the temperature control zone is configured to control the temperature of the interior of the housing.

Capillary array cartridge for capillary electrophoresis systems

The fluid infusion system is disclosed that includes a pump housing that has a reservoir cavity and is designed to be pocketable. The reservoir cavity has a rim and helical coupling features formed on an interior face of the reservoir cavity. The fluid infusion system further has a reservoir that is removable from the reservoir cavity and the reservoir also has an open end. A removable cap coupled to the pump housing is also included in the fluid infusion system. The cap has corresponding coupling features, an exterior surface and a tab. The corresponding coupling features are defined to couple the cap to the pump housing while the tab is defined as a ridge that extends away from the exterior surface. The tab further has a port to accommodate fluid flow from the reservoir where the port defines and axis of rotation such that torque applied to the tab about the axis of rotation disengages the coupling between the cap and the pump housing. Further included in the infusion system is a guard that is removably coupled to the pump housing. The guard has a slot defined to immobilize rotation of the tab about the axis of rotation.

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Vista, CA, United States of America

Dan Kline