Amgen Inc.

Dan Horne

Craig E Masse

Ning Chen

Vinod Francis Patel

Brian K Albrecht

Matthew M Weiss

Jennifer Rebecca Allen

Stephen A Hitchcock

Holger Monenschein

Patricia Lopez

Thomas T Nguyen

Qiufen May Xue

Matthew R Kaller

Wenge Zhong

Yuan Cheng

Scott S Harried

Ted Charles Judd

Daniel La

Michael D Bartberger

Paul E Harrington

James A Brown

Russell Graceffa

Lewis D Pennington

James Richard Falsey

Thomas Nixey

Randall W Hungate

Charles Kreiman

Bryant Yang

Michael D Croghan

Andreas Reichelt

Shannon Rumfelt

Kaustav Biswas

Stuart C Chaffee

Frank Chavez

Guomin Yao

Frenel Fils DeMorin

Ryan Brown

Dean Hickman

Kelvin Sham

Essa Hu

Roxanne Kunz

Alex Pickrell

Mike Frohn

Rob Rzasa

Tom Nguyen

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, W, R, R, R, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

Beta-secretase modulators and methods of use

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Thousand Oaks, CA, United States of America

Dan Horne