Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Dan Gibson

Yechezkel Barenholz

Simon Benita

Taher Nassar

Jehoshua Katzhendler

Yousef Najajreh

Aiman Abu Ammar

Ada Schlossman

Yousuf Najajreh

Elena Khazanov

Provided are Pt (IV) lipophilic derivatives for improved drug performance in cancer therapy, as well as nanocarriers including the same.

Pt (IV) derivatives and nanocarriers comprising them

The present invention relates to novel types of peptide nucleic acids (PNAS) with improved properties. In particular, it relates to positively charged PNA units having an ethylene linker between the backbone and the nucleobase, to oligonucleotide analogs comprising these units, to oligomers comprising these units, and to the use of positively charged PNAs as novel delivery agents with therapeutic and diagnostic applications including for antisense therapy.

Positively-charged peptide nucleic acid analogs with improved properties

The present invention concerns novel platinum complexes in which at least one of the amine ligand is a non-planar heterocyclic aliphatic amine. The platinum complexes may be in a trans or cis configuration and were found to posses therapeutic activites. Thus, the present concerns novel platinum complexes, pharmaceutical compositions comprising them and other uses thereof.

Platinum complexes and their use in therapy

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Jerusalem, Israel

Dan Gibson