Verenium Corporation

Diversa Corporation

Joule Unlimited Technologies, Inc.

Basf Enzymes LLC

Joule Unlimited, Inc.

Basf Se Corporation

Other

Diverso Corporation

Dsm IP Assets B.v.

Bp Corporation North America Inc.

Dan Eric Robertson

Jay Milton Short

John H Reid

Dennis Murphy

Nikos Basil Reppas

Brian D Green

Grace DeSantis

Kevin A Gray

Frank Anthony Skraly

Christian Perry Ridley

Jennifer Ann Chaplin

Mark Joseph Burk

David Arthur Berry

Noubar Boghos Afeyan

David Paul Weiner

Ellen Chi

Mark Madden

Aileen Milan

Martha Sholl

Nelson Robert Barton

Sylke Haremza

Toby Howard Richardson

Janne Samuli Kerovuo

Ryan T McCann

Oliver Koch

Tilo Habicher

Sriram Kosuri

Darcy Madden, Legal Representative

Peter Luginbuhl

Eileen O'Donoghue

James B Garrett

Regina Wilpiszeski

Robert S Adhikary

Indrajit Sanyal

Grace Desantis

Tim S Hitchman

David E Lam

Ronald V Swanson

Xuqiu Tan

Robert Christopher Brown

Geoff Hazlewood

Keith A Kretz

Giselle G Janssen

Joel Kreps

Svetlana Gramatikova

Amit Vasavada

Jincai Li

Anna Kosmotka

Steven Link

Charles Isaac

Wilhelmus P Van Hoek

Adrian Badillo

Roderick James Fielding

Blake G Sturgis

Yoko Phillips

Masao Hiraiwa

Mark (deceased) Madden

Eric J Mathur

Patrick Vernon Warren

David M Weiner

Paul S Zorner

Anthony M Maffia, Iii

Giselle Janssen

Jacob Carter Harrison

Patrick V Warren

Michael Connor

Peter Luginbühl

Eric James Devroe

William Baum

Anthony M Maffia

Marcy Madden, Legal Representative

Brian Green

Roderick Fielding

Ryan Mccann

Robert C Brown

Joel A Kreps

Eileen O'donoghue

Provided herein are isolated laccase enzymes and nucleic acids encoding them. Also provided are mediators for laccase reactions. Also provided herein are methods for using laccases to oxidize lignins, other phenolic, and aromatic compounds, such as for bio-bleaching and decolorization of wood pulp under high temperature and pH conditions to facilitate a substantial reduction in use of bleaching chemicals, as well as for treatment of fibers.

Laccases for bio-bleaching

The invention relates to haloalkane dehalogenases and to polynucleotides encoding the haloalkane dehalogenases. In addition methods of designing new dehalogenases and method of use thereof are also provided. The dehalogenases have increased activity and stability at increased pH and temperature.

Dehalogenases, nucleic acids encoding them and methods for making and using them

Provided herein are isolated laccase enzymes and nucleic acids encoding them. Also provided are mediators for laccase reactions. Also provided herein are methods for using laccases to oxidize lignins and other phenolic and aromatic compounds, such as for bio-bleaching and decolorization of wood pulp under high temperature and pH conditions to facilitate a substantial reduction in use of bleaching chemicals, as well as for treatment of fibers.

The present disclosure relates to methods and compositions for engineering photoautotrophic organisms to convert carbon dioxide and light into fatty acid esters and other molecules, including biofuels. The molecules are then secreted by the organism into a growth medium.

Ethanol production in microorganisms

The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.

Nitrilases, nucleic acids encoding them and methods for making and using them

The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof.

Engineered CO2 fixing microorganisms producing carbon-based products of interest

The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert inorganic carbon and light into n-alkanes, and in particular the use of such organisms for the commercial production of n-alkanes and related molecules.

Photoalkanogens with increased productivity

The present disclosure identifies methods and compositions for modifying photoautotrophic organisms, such that the organisms efficiently convert carbon dioxide and light into compounds such as esters and fatty acids. In certain embodiments, the compounds produced are secreted into the medium used to culture the organisms.

Methods and compositions for the recombinant biosynthesis of fatty acids and esters

Nitrilases

The invention provides nitrilases and methods for making and using them, and in one aspect, provides methods for producing enantiomerically pure &#x3b1;-substituted carboxylic acids, such as, for example, &#x3b1;-amino acids and &#x3b1;-hydroxy acids. In one aspect, methods of the invention combine an aldehyde or ketone with a cyanide and ammonia or an ammonium salt or an amine, in the presence of a nitrilase or a polypeptide having nitrilase activity, to stereoselectively hydrolyze the amino nitrile or cyanohydrin intermediate under conditions sufficient to produce the carboxylic acid.

Nitrilases and methods for making and using them

Growing community of inventors

Belmont, MA, United States of America

Dan Eric Robertson