Cephalon, Inc.

Daming Feng

Bruce D Dorsey

Koc-Kan Ho

Tao Guo

Henry Joseph Breslin

Gregory R Ott

Rabindranath Tripathy

Craig A Zificsak

James L Diebold

Diane E Gingrich

Karen L Milkiewicz

Keith S Learn

Benjamin J Dugan

Eugen F Mesaros

Linda Weinberg

Theodore L Underiner

Gregory J Wells

Joseph Lisko

Jay P Theroff

Gulzar Ahmed

Jason C Wagner

Matthew A Curry

Tho V Thieu

Rong-qiang Liu

Jason Burke

Ming You

Adolph Bohnstedt

Joseph G Lisko

Jonathan Parrish

Rong-Qiang Liu

Karen Milkiewicz

The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R, R, R, R, R, A, A, A, A, and A, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.

Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-MET inhibitors

The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R, R, R, R, R, A, A, A, A, and A, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders. 

Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-Met inhibitors

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East Windsor, NJ, United States of America

Daming Feng