Horiba Abx Sas

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Centre National De La Recherche Scientifique

Universitè De Montpellier

Iprasense Sas

Horiba Abx Sas / Horiba Ltd

Damien Isebe

Pierre Blandin

Simon Mendez

Pierre Taraconat

Cedric Allier

Lionel Herve

Didier Cremien

Geoffrey Esteban

Aurelien Daynes

Anais Ali-Cherif

Estelle Gremion

Anais Ali Cherif

Franck Nicoud

Franck Nlcoud

A medical analysis device with cellular impedance signal processing features a memory arranged to receive pulse data sets, with each pulse data set including impedance value data that are associated each time with a time marker. The pulse data sets together represent a curve of cellular impedance values that are measured as a cell passes through a polarised opening. The device further includes a classifier in communication with the memory. The classifier may feature a convolutional neural network that receives the pulse data sets as input. The classifier is provided with at least one convolutional layer, which convolutional layer has a depth greater than or equal to 3, and at least two fully connected layers, in addition to an output layer rendering a cell classification from which a pulse data set is derived.

Medical analysis device with impedance signal processing

A device for medical analyses with cellular impedance signal processing comprises a memory () arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarized opening, a computer () arranged to process a pulse data set by determining a rotation value indicating whether the cell from which this pulse data set has been taken has undergone a rotation during its passage through the polarized opening, and a classifier () arranged to retrieve from the computer () a given pulse data set, and to use the resulting rotation value to classify the given pulse data set in a rotation pulse data set group () or a rotationless pulse data set group ().

Device for medical analyses with impedance signal processing

The invention is a method for estimating a representative volume of particles of interest () immersed in a sample, the sample extending in at least one plane, referred to as the sample plane (P), the sample comprising a sphering agent, capable of modifying the shape of the particles, the method comprising the following steps: a) illuminating the sample by means of a light source (), the light source emitting an incident light wave () propagating towards the sample () along a propagation axis (Z); b) acquiring, by means of an image sensor (), an image (I) of the sample (), formed in a detection plane (P), the sample being arranged between the light source () and the image sensor (), each image being representative of a light wave () referred to as an exposure light wave, to which the image sensor () is exposed under the effect of illumination; c) using the image of the sample (I), acquired during step b), and a holographic propagation operator, to calculate a complex expression (A (x, y, z)) of the exposure light wave () in different positions relative to the detection plane; the method comprising a step of estimating the representative volume (AA) of the particles of interest () depending on the complex expressions calculated during step c).

Optical method for estimating a representative volume of particles present in a sample based on a size of each region of interest

A method for holographic characterization of a particle contained in a sample, based on an image, or hologram, of the sample obtained by an image sensor when the sample is illuminated by a light source. The hologram is the subject of a holographic reconstruction, to obtain a reference complex image, representative of the light wave transmitted by the sample in a reconstruction plane. A holographic propagation operator is applied to the reference complex image, to obtain a plurality of secondary complex images, from which a profile is determined describing the change in an optical feature of the light wave transmuted by the sample along the axis of propagation of the light wave.

Holographic method for characterizing a particle in a sample

The present application relates to: (i) a sampler device for taking a sample of biological fluid, which comprises a capillary component, and a base rigidly connected to said capillary component and provided with a first connector capable of being reversibly attached in a leaktight manner to a second connector of a dispensing device; (ii) a dispensing device which also comprises means for transferring diluting fluid which open into said second connector. The application also relates to a biological analysis apparatus implementing the sampler and dispensing devices and to a method for sampling and dispensing a biological fluid.

Device and method for sampling and dispensing a biological fluid using a capillary tube, and biological analysis apparatus

Growing community of inventors

Grabels, France

Damien Isebe