University of Rochester

University of Kansas

Damian J Krysan

Daniel Patrick Flaherty

Paul M Dunman

Louis DiDone

Bonnie K Baxter

Provided herein are compositions and methods for treating or preventing infection.

Methods and compositions for treating infection

Provided are methods of treating or preventing a fungal infection in a subject. The methods comprise selecting a subject with or at risk of developing a fungal infection and administering to the subject a therapeutically effective amount of toremifene and fluconazole or derivatives thereof.

Compounds for anti-fungal treatment

Provided are methods of treating or preventing a fungal infection in a subject. The methods comprise identifying a subject with or at risk of developing a fungal infection and administering to the subject a therapeutically effective amount of an inhibitor or a fungal phosphoinositide-dependent kinase 1 (PDK-1) or a homolog thereof. Inhibition of the fungal PDK-1 or homolog thereof results in the treatment or prevention of a fungal infection in the subject. Also provided are compositions comprising an inhibitor of a fungal phosphoinositide-dependent kinase 1 (PDK-1) or a homolog thereof, and a pharmaceutically acceptable carrier.

Growing community of inventors

Pittsford, NY, United States of America

Damian J Krysan