The Macfarlane Burnet Institute for Medical Research and Public Health Limited

Reef Pharmaceuticals Pty Ltd

Damian Francis John Purcell

Fan Li

David Andrew Anderson

Roy Michael Robins-Browne

Grant Thomas Rawlin

Robert John Center

Gottfried Lichti

Marit Kramski

A method for enhancing an immune response to a nucleic acid vaccine comprising administering to an animal a nucleic acid construct encoding a fusion protein comprising a processing component and an antigenic polypeptide of interest wherein said processing component provides heterogeneous processing of the antigenic polypeptide when the nucleic acid construct is expressed in a host cell and a resulting enhancement of the immune response. The processing component is derived from an N-terminal portion of PORF2 of Hepatitis E virus.

Nucleic acid construct encoding a processing component derived from the N-terminal region of the hepatitis virus ORF2, and an antigenic polypeptide

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Balwyn North, Australia

Damian Francis John Purcell