Other

Biomira, Inc.

Oncothyreon Inc.

Damayanthi Yalamati

Rajeshwar Singh

B Michael Longenecker

R Rao Koganty

Wladyslaw A Budzynski

Rao R Koganty

Mark J Krantz

Zi-Hua Jiang

Sham Gandhi

Myung-Gi Baek

Mimi Bach

Michael Longenecker

Praveen Baradi

Rao Koganty

Compounds of formula I that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase, pharmaceutical compositions including such compounds and methods of treating diseases, conditions or disorders utilizing such compounds and compositions. 

Substituted tetrahydropyridine derivatives as IDO-1 inhibitors and uses thereof

Covalently lipidated oligonucleotides comprising the CpG dinucleotide unit, or an analogue thereof, may be used as immunostimulatory agents to protect against a disease caused by a cancer cell or a pathogen, either alone or in conjunction with immunogens and/or non-immunological agents. Lipidated oligonucleotides with special backbones, lipidated oligonucleotides with fewer than eight nucleotides, and lipidated oligonucleotides comprising a plurality of CpG dinucleotide-containing segments connected by a long internucleoside linkage are of particular interest. These compounds are also novel per se.

Immunostimulatory, covalently lipidated oligonucleotides

New synthetic Lipid-A analogs based on monosaccharide (1) and disaccharide (2) derivatives were designed and prepared in the present invention. Both structures (1) and (2) incorporate novel lipid structures (3) and (4) that are not found in nature. Also, novel disaccharide Lipid-A structures (2) that incorporate novel contingents of uniform lipids and where R, Rand Rare the same substitution group of structure (III) were synthesized. Liposome formulations containing totally synthetic components such as synthetic Lipid-A and synthetic lipopeptide derived from tumor-associated MUC1 mucin are described along with their therapeutic utility. Comparative test results of immunostimulating properties and toxicity of Lipid-A analogs (1) and (2) are included.     

Synthetic lipid-a-analogs and uses thereof

Growing community of inventors

Edmonton, Canada

Damayanthi Yalamati