Merck + Co., Inc.

Daljit S Dhanoa

William J Greenlee

Thomas F Walsh

Kenneth J Fitch

Arthur A Patchett

Ralph A Rivero

Scott William Bagley

David L Williams

Prasun K Chakravarty

David G Hangauer

James R Tata

Nancy J Kevin

Douglas J Pettibone

Theodore P Broten

Daniel F Veber

Richard B Toupence

Elizabeth M Naylor

Anna Chen

Jay M Matthews

Lihu Yang

William H Parsons

Ann E Weber

Wallace T Ashton

Gerard R Kieczykowski

Thomas A Halgren

Phenoxyphenylacetic acid derivatives

Phenoxyphenylacetic acids and derivatives of the general structural formula I ##STR1## have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, benign prostatic hyperplasia, inflammatory diseases including Raynaud's disease and asthma.

Biphenyl compounds useful or endothelin antagonists

Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1## wherein the substituents are as defined in the claims.

Angiotensin II antagonists incorporating a substituted benzyl element

Phenoxyphenylacetic acids and derivatives of general structural formula I ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, inflammatory diseases, Raynaud's disease, and endotoxic shock, and asthma.

Quinazolinones substituted with phenoxyphenylacetic acid derivatives

Phenoxyphenylacetic acids and derivatives of general structural formula I ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebal and cardiac ischemia, myocardial infarction, inflammatory diseases, Raynaud's disease, and endotoxic shock, and asthma.

Phenoxyphenylacetic acids and derivatives of general structural formula I ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, congestive heart failure, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, inflammatory diseases, Raynaud's disease, and endotoxic shock, and asthma.

Six membered ring fused imidazoles substituted with phenoxyphenylacetic

Phenoxyphenylacetic acids and derivatives of general structural formula I have endothelin ##STR1## antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, congestive heart failure, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, inflammatory diseases, Raynaud's disease, and endotoxic shock, and asthma.

Six-membered ring fused imidazoles substituted with phenoxyphenylacetic

Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1##

Quinazolinone, triazolinone and pyrimidinone angiotensin II antagonists

Compounds of the formula: ##STR1## are disclosed. These compounds inhibit the angiotensinogen-cleaving action of the natural proteolytic enzyme, renin, and are useful in treating, preventing or managing renin-associated hypertension, hyperaldosteronism, congestive heart failure, and glaucoma.

Cyclic renin inhibitors containing

Angiotensin II antagonists incorporating a substituted pyridoimidazolyl

Substituted imidazoles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I, are useful as angiotensin II antagonists. ##STR1##

Imidazole angiotensin II antagonists incorporating a substituted benzyl

Substituted triazoles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I, are useful as angiotensin II antagonists. ##STR1##

Triazole angiotensin II antagonists incorporating a substituted benzyl

Substituted heterocycles attached through a methylene bridge to novel substituted indole or dihydroindole derivative of the Formula I are useful as angiotensin II antagonists. ##STR1##

Angiotensin II antagonists incorporating a substituted indole or

There are disclosed substituted indoles and dihydroindoles of Formula I which are useful as angiotensin II antagonists. ##STR1##

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Tinton Falls, NJ, United States of America

Daljit S Dhanoa