Sonivie Ltd.

Dalit Shav

Or Shabtay

Charles S Carignan

Talia Cohen Keizman

Daniel Naor

Maya Rosenstein

Ofek Admon

Some embodiments relate to a method of reducing excess mucosa production and/or secretion in the respiratory tract, comprising: introducing into a respiratory tract lumen a device configured for damaging nerve tissue or blocking neural conduction in the surroundings of said lumen, the device comprising a plurality of energy emitters; positioning the energy emitters of the device inside the lumen at a distance from walls of the lumen; and activating the energy emitters to emit energy suitable to damage the nerve tissue enough to suppress parasympathetic nerve activity which causes excess mucosa production and/or secretion.

Devices and methods for reducing parasympathetic nerve activity in patients with a respiratory syndrome

Disclosed herein is a therapeutically active agent usable in the treatment of pulmonary arterial hypertension (PAH), for use in the treatment of pulmonary arterial hypertension, as well as methods of treating PAH, said treatment and methods comprising administering such an active agent and effecting pulmonary artery denervation in the subject. In some aspects, a sub-therapeutically effective amount of the active agent is administered. In some aspects, the method is devoid of administering such an active agent for at least one month subsequent to the denervation. Further disclosed is a method of treating PAH comprising determining a responsiveness of the subject to at least one therapeutically active agent usable in treating PAH; and effecting pulmonary artery denervation in a subject responsive to the active agent(s).

Pulmonary hypertension treatment

Some embodiments relate to a method of reducing excess mucosa production and/or secretion in the respiratory tract, comprising: introducing into the lumen of the trachea or the lumen of the bronchi a device configured for damaging nerve tissue or blocking neural conduction in the surroundings of the lumen; and activating the device to damage the nerve tissue enough to suppress parasympathetic nerve activity which causes the excess mucosa production and/or secretion.

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Glen Rock, NJ, United States of America

Dalit Shav