Advanced Collagen Science LLC

Esm Technologies, LLC

Shanghai Qisheng Biological Preparation Co., Ltd.

Euclid Systems Corporation

Merz North America, Inc.

Shanghai Haohai Biological Technology Co., Ltd.

Dermelle, LLC

3d Vision Systems, LLC

New Life Resources, LLC

C. R. Bard, Inc.

Collagenesis, Inc.

Dale Paul DeVore

Charles D Kelman

Leonard B Miller

Todd Byrne

Robert J Brooks

Frank Daniel Long

Bruce H DeWoolfson

Eliot Lazar

Randall Gene Adams

Braden Patrick DeVore

Robert Voigts

Embodiments of the present invention are directed to devices and apparatus for administering collagen modifier compounds to the dermis of skin.

Device, dispensing apparatus and methods for administering collagen modifier compounds

The present invention is directed to injectable acid soluble collagen compositions comprising a neutralized solution of an acid soluble collagen, EDTA and preferably a polyol, wherein the composition is injectable at physiological pH and the acid soluble collagen polymerizes upon exposure to tissue. The invention is suitable for use in soft tissue augmentation, promoting soft tissue regeneration and coating medical implants and devices.

Injectable in situ polymerizable collagen composition

Embodiments of the present invention are directed to methods and articles of manufacture to treat skin to improve and/or increase hydration, pliability, and thickness for improved texture, feel and appearance. Embodiments feature applying an effective amount of an acetylation agent to natural dermal collagen under reaction conditions to react the natural dermal collagen with the acetylation agent to form a modified collagen. The modified collagen has a higher net charge and higher net charge density than natural dermal collagen. The modified collagen improves or increases one or more skin characteristics consisting of hydration, pliability and thickness.

Methods and articles of manufacture for the treatment of skin

A composition of matter and method for preparation of a tissue augmentation material. A polysaccharide gel composition is prepared with rheological properties selected for a particular selected application. The method includes preparing a polymeric polysaccharide in a buffer to create a polymer solution or gel suspending properties in the gel and selecting a rheology profile for the desired tissue region.

Implantation compositions for use in tissue augmentation

The disclosure provides collagen-based constructs for use in drug delivery.

Collagen-based implants for sustained delivery of drugs

The present invention relates to anti-inflammatory activity of eggshell membrane, processed eggshell membrane preparations and eggshell membrane isolates. The invention is directed to eggshell membrane compositions exhibiting anti-inflammatory activity as measured by effects on down-regulating pro-inflammatory plasma antigens in mammals that had orally ingested such compositions. This information supports the potential benefits from administration of naturally occurring material found in eggshell membrane, processed eggshell membrane, eggshell membrane isolates and combinations to reduce pain and inflammation associated with arthritis and other inflammatory conditions.

Anti-inflammatory activity of eggshell membrane and processed eggshell membrane preparations

The present disclosure describes novel methods for localized and controlled staining of intact corneal tissue surfaces to provide therapeutic benefits in ophthalmic applications, such as for example, the correction of iris defects, the correction of corneal tissue scarring, and the creation of a pupil in aniridia. A first method for staining tissue surfaces is directed to covalently bonding sulfonic acid dyes to deprotonated proteins in tissue. Another disclosed method is directed to staining corneal tissue surfaces with black sulfonic acid dye compositions, particularly for forming black rings on the corneal surface.

Method for localized staining of an intact corneal tissue surface

Compositions and methods of preparing compositions containing hyaluronic acid derived from eggshell membrane are disclosed. The compositions can contain essentially pure hyaluronic acid or hyaluronic acid in combination with other naturally occurring constituents derived from eggshell membrane. In another aspect, the invention is directed to a method of treating a mammal that will benefit from the administration of hyaluronic acid, which includes administering to the mammal a composition containing hyaluronic acid derived from eggshell membrane.

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Chelmsford, MA, United States of America

Dale Paul DeVore