Chemocentryx, Inc.

Cell Genesys, Inc.

Gbp Ip, LLC

Dale John Talbot

Thomas J Schall

Thomas L Dull

James G McArthur

Andrew Simmons

Ryan McGuinness

Michael Kelly

Lisa V Tsui

Daniel J Dairaghi

Michael R Hanley

Zhenhua Miao

Jennifa Gosling

Maureen Howard

Brett Anthony Premack

Robert Berkovitz

Recombinant lentiviruses and transfer vectors for transgene delivery as well as methods for gene therapy using such vectors are disclosed. The invention provides a third generation lentiviral packaging system and a set of vectors for producing recombinant lentiviruses, as well as novel tissue specific enhancer and promoter elements useful for optimizing liver specific transgene delivery. The transgene is preferably a blood clotting factor such as human factor IX (hFIX) or human factor VIII (hFVIII) and can be used for treatment of hemophilia.

Lentiviral vectors featuring liver specific transcriptional enhancer and methods of using same

This application relates generally to enhancing immune responses. Such immune responses may be elicited by vaccine administration. Compositions and methods for inducing or enhancing an immune response to an antigen are provided. The compositions and methods are useful for, among other things, vaccine formulation for therapeutic and prophylactic vaccination (immunization) and for production of useful antibodies (e.g., monoclonal antibodies for therapeutic or diagnostic use).

Compositions for inducing an immune response

Liver specific transcriptional enhancer

The invention provides polypeptides and polynucleotides encoding a novel chemokine receptor, CCX CKR. The invention further provides reagents and methods for identifying agents that modulate the activity or expression of the receptors, as well as methods for detecting receptor expression.

Method for identifying a modulator of the binding of CCX CKR polypeptide to a chemokine

Methods for identifying modulators of CCX CKR activity

Lentiviral vectors encoding clotting factors for gene therapy

Growing community of inventors

San Francisco, CA, United States of America

Dale John Talbot