Surmodics, Inc.

Bsi Corporation

Henkel Corporation

General Mills Chemicals, Inc.

Surmodics Ivd, Inc.

Dale G Swan

Stephen J Chudzik

Melvin J Swanson

Aleksey V Kurdyumov

Richard A Amos

Terrence Phillip Everson

Ralph A Chappa

Ronald F Ofstead

Sean M Stucke

Peter H Duquette

Joram Slager

Michael J Burkstrand

Patrick E Guire

Nathan Lockwood

Robert W Hergenrother

Joseph Andrew Chinn

Sheau-Ping J Hu

Charles A Hastings

Jerry C Hansen

Gary W Opperman

Joseph Schmidt McGonigle

Dwight E Peerman

Bruce M Jelle

Emily R Rolfes Meyering

Mark W Josephson

Shannon Wadman

H Gordon Kanten

Joseph Ventura

Darin DuMez

Pam Read, Legal Representative

Joseph Schmidt Mcgonigle

Sheau-Ping Hu

Joseph A Chinn

Darin Dumez

Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a vinyl amine polymer. Methods of making the delivery composition, as well as kits and methods of use are also included herein.

Compositions and methods for delivery of hydrophobic active agents

Described herein is a degradable linking agent of formula Photo-LG-Photo, wherein Photoand Photoindependently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.

Photoactivatable crosslinker

The invention is directed to latent reactive and polymerizable derivatives of fluorescent stilbene-based compounds. The compounds can be used to provide articles with a fluorescence property, such as medical devices (e.g., catheters). The fluorescent compounds can be used in association with polymers, or can be incorporated into polymers, and the polymers used in a coating composition on the article surface. The compounds allow for visual or machine inspection of coating properties such as uniformity of coverage.

Stilbene-based reactive compounds, polymeric matrices formed therefrom, and articles visualizable by fluorescence

Silane-functionalized hydrophobic &#x3b1;(1&#x2192;4)glucopyranose polymers and polymeric matrices are described. Biodegradable matrices can be formed from hydrophobic &#x3b1;(1&#x2192;4)glucopyranose polymers with reactive pendent silyl ether groups. Reaction of the silyl ether groups provides improved matrix formation through bonding to a device surface of a device, polymer-polymer crosslinking, or both. Biodegradable matrices can be used for the preparation of implantable and injectable medical devices, including those that release a bioactive agent.

Silane-functionalized hydrophobic &#x3b1;(1&#x2192;4)glucopyranose polymers and polymeric matrices for implantation or injection

The invention provides emulsion compositions that include a hydrophobic compound and an arylboronic acid. An exemplary emulsion comprises a hydrophobic polymer and a halogenated arylboronic acid. Use of an arylboronic acid provides the emulsion with exceptional stability. The stability provides advantages for the formation of articles formed from the emulsion, including microparticles, as well as other implantable or injectable medical articles having polymeric matrices.

Emulsions containing arylboronic acids and medical articles made therefrom

Hydrophobic &#x3b1;(1&#x2192;4)glucopyranose polymers with enhanced degradation properties are described. Between the &#x3b1;(1&#x2192;4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a chemistry that facilitates degradation of the polymer. Diester and carbonate ester linker chemistries are exemplified. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described.

Hydrophobic polysaccharides with diester- or carbonate ester-containing linkages having enhanced degradation

Biodegradable coatings and articles that include natural biodegradable polysaccharides are described. The coatings and articles are formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups.

Coatings including natural biodegradable polysaccharides and uses thereof

Medical articles having a body member including natural biodegradable polysaccharides are described. The body member is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups. The body member can also include a bioactive agent which can be released to provide a therapeutic effect to a patient.

Articles including natural biodegradable polysaccharides and uses thereof

Biodegradable coatings that include natural biodegradable polysaccharides are described. The coating is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups.

Coatings for medical articles including natural biodegradable polysaccharides

The present invention provides method and materials for forming a polymeric matrix having improved biocompatible properties. A polymerization accelerator is provided that includes an N-vinyl group and a biocompatible functional group. The polymerization accelerator is particularly useful for the polymerization of macromers, which can be used to form biocompatible polymeric coatings on the surface of biological materials, such as cells and tissue.

Composition containing biocompatible polymerization accelerator and polymerizable material

Positively-charged initiator polymers having a polymerization initiator group and a cationic portion are provided. The initiator polymers can be used with a polymerizable material for the formation of a polymeric matrix on a surface. The initiator polymers are particularly useful for cell encapsulation using macromers.

Encapsulated cells using positively-charged initiator polymer

Growing community of inventors

St. Louis Park, MN, United States of America

Dale G Swan