Axsun Technologies, Inc.

Massachusetts Institute of Technology

Volcano Corporation

Other

Corning Incorporated

Excelitas Technologies Corp.

Philips Image Guided Therapy Corporation

Kineolabs, Inc.

Dale C Flanders

Walid A Atia

Mark E Kuznetsov

Peter S Whitney

Bartley C Johnson

Henry Ignatius Smith

Petros Amestis Kotidis

Michael Francis Miller

Jeffrey A Korn

Xiaomei Wang

Minh Van Le

Jonathan Robert Coppeta

James W Getz

Christopher C Cook

Steven F Nagle

Robert K Jenner

Carlos R Melendez

Livia M Racz

Brian Goldberg

Mona Masghati

Robert L Payer

Michael W Geis

James N Walpole

Zong-Long Liau

Stanley R Shanfield

Randal A Murdza

David C Shaver

Margaret B Stern

Thomas D Williams

Muriel A Dalomba

Stewart S Austin

Carl O Bozler

Martin Arnold Schmidt

Xinfa Ma

Dimitri A Antoniadis

Theodore M Lyszczarz

Steven W Rabe

Richard Dee

Randal A Salvatore

Eric E Fitch

David B West

Yu Nathan Li

Steven C Fawcett

Walter R Buchwald

Lawrence McDermott

Vaibhav Mathur

Douglas A Simpson

L James Newman, Iii

Arvind Baliga

Bart Ley C Johnson

Optical coherence tomography (OCT) probe and system designs are disclosed that minimize the effects of mechanical movement and strain to the probe to the OCT analysis. It also concerns optical designs that are robust against noise from the OCT laser source. Also integrated OCT system-probes are included that yield compact and robust electro-opto-mechanical systems along with polarization sensitive OCT systems.

Integrated optical coherence analysis system

A microelectromechanical systems (MEMS)-tunable vertical-cavity surface-emitting laser (VCSEL) in which the MEMS mirror is bonded to the active region. This allows for a separate electrostatic cavity that is outside the laser's optical resonant cavity. Moreover, the use of this cavity configuration allows the MEMS mirror to be tuned by pulling the mirror away from the active region. This reduces the risk of snap down. Moreover, since the MEMS mirror is now bonded to the active region, much wider latitude is available in the technologies that are used to fabricate the MEMS mirror. This is preferably deployed as a swept source in an optical coherence tomography (OCT) system.

OCT system with bonded MEMS tunable mirror VCSEL swept source

An optical detector system comprises a hermetic optoelectronic package, an optical bench installed within the optoelectronic package, a balanced detector system installed on the optical bench. The balanced detector system includes at least two optical detectors that receive interference signals. An electronic amplifier system installed within the optoelectronic package amplifies an output of at least two optical detectors. Also disclosed is an integrated optical coherence tomography system. Embodiments are provided in which the amplifiers, typically transimpedance amplifiers, are closely integrated with the optical detectors that detect the interference signals from the interferometer. Further embodiments are provided in which the interferometer but also preferably its detectors are integrated together on a common optical bench. Systems that have little or no optical fiber can thus be implemented.

Optical coherence tomography (OCT) system having integrated detector and analysis systems

An optical coherence analysis system uses a laser swept source that is constrained to operate in a mode locked condition. This is accomplished by synchronously changing the laser cavity's gain and/or phase based on the round trip travel time of light in the cavity. Many high-speed wavelength swept laser sources emit pulses synchronized with the round trip time of the cavity as part of a nonlinear optical frequency red shifting process. Stable pulsation is associated with smooth tuning and low relative intensity noise. Addition of mode-locking methods to this class of lasers can control and stabilize these lasers to a low clock jitter and RIN state, and in specific cases allow long-to-short wavelength tuning in addition to the usual short-to-long (red shifting). The laser may comprise a SOA (), a tunable Fabry-Perot-Filter () as one reflector and an Output coupler () in an optical fiber () to adjust the cavity length.

Laser swept source with controlled mode locking for OCT medical imaging

A frequency swept laser source for TEFD-OCT imaging includes an integrated clock subsystem on the optical bench with the laser source. The clock subsystem generates frequency clock signals as the optical signal is tuned over the scan band. Preferably the laser source further includes a cavity extender in its optical cavity between a tunable filter and gain medium to increase an optical distance between the tunable filter and the gain medium in order to control the location of laser intensity pattern noise. The laser also includes a fiber stub that allows for control over the cavity length while also controlling birefringence in the cavity.

Optical coherence tomography laser with integrated clock

An optical coherence tomography system utilizes an optical swept laser that has cavity length compensator that changes an optical length of the laser cavity for different optical frequencies to increase the length of the laser cavity for lower optical frequencies. Specifically, a spectral separation between longitudinal cavity modes of the laser cavity is shortened or alternatively lengthened as a passband of a cavity tuning element sweeps through a scanband of the swept optical signal. In some examples, the compensator is implemented as two gratings. In others, it is implemented as a chirped grating device.

OCT swept laser with cavity length compensation

An intravascular sensor system including an array of pressure and/or temperature sensors for detecting pressure and/temperature. In one example, the sensors are interrogated with an optical catheter. In this example, the swept source is able to acquire both image and pressure/temperature data of a patient's vessel or artery. In another example, the intravascular pressure sensor system has a sheath embedded with pressure sensors in the sheath wall. Other examples include the process of making and using the intravascular pressure sensor system.

Sheath with optically interrogatable sensors

An integrated swept wavelength optical source uses a filtered ASE signal with an optical amplifier and tracking filter. This source comprises a micro optical bench, a source for generating broadband light, a first tunable Fabry Perot filter, installed on the bench, for spectrally filtering the broadband light from the broadband source to generate a narrowband tunable signal, an amplifier, installed on the bench, for amplifying the tunable signal, and a second tunable Fabry Perot filter, installed on the bench, for spectrally filtering the amplified tunable signal from the amplifier. A self-tracking arrangement is also possible where a single tunable filter both generates the narrowband signal and spectrally filters the amplified signal. In some examples, two-stage amplification is provided. The use of a single bench implementation yields a low cost high performance system. For example, polarization control between components is no longer necessary.

Filtered ASE swept source for OCT medical imaging

An optical coherence analysis system comprising: a first swept source that generates a first optical signal that is tuned over a first spectral scan band, a second swept source that generates a second optical signal that is tuned over a second spectral scan band, a combiner for combining the first optical signal and the second optical signal for form a combined optical signal, an interferometer for dividing the combined optical signal between a reference arm leading to a reference reflector and a sample arm leading to a sample, and a detector system for detecting an interference signal generated from the combined optical signal from the reference arm and from the sample arm. In embodiments, the swept sources are tunable lasers that have shared laser cavities.

Integrated dual swept source for OCT medical imaging

An optical coherence analysis system comprising: a first swept source that generates a first optical signal that is tuned over a first spectral scan band, a second swept source that generates a second optical signal that is tuned over a second spectral scan band, a combiner for combining the first optical signal and the second optical signal to form a combined optical signal, an interferometer for dividing the combined optical signal between a reference arm leading to a reference reflector and a sample arm leading to a sample, and a detector system for detecting an interference signal generated from the combined optical signal from the reference arm and from the sample arm.

Integrated dual swept source alternating same scan band for OCT medical imaging

A frequency swept laser source that generates an optical signal that is tuned over a spectral scan band at single discrete wavelengths associated with longitudinal modes of the swept laser source. Laser hopping over discrete single cavity modes allows long laser coherence length even under dynamic very high speed tuning conditions. A ramp drive to the laser is used to linearize laser frequency tuning. A beam splitter is used to divide the optical signal between a reference arm leading to a reference reflector and a sample arm leading to a sample. A detector system detects the optical signal from the reference arm and the sample arm for generating depth profiles and images of the sample.

Swept frequency laser for FD OCT with intracavity element and method of operation

Growing community of inventors

Lexington, MA, United States of America

Dale C Flanders