Chongqing Upgra Biotechnology Co., Ltd.

Dajun Li

Qian Zhang

Gaoquan Li

Bin Wang

Xiaoling Ding

Huiyu Chen

Yuanqiang Wang

Yongchen Peng

Yue Yang

Xiangwei Yang

Xi Liu

Qiang Luo

Jianhuan Li

Yusong Wei

Diedie Li

Jia Gao

Jie Lou

Yanxia Heng

Xiafan Zeng

Yuyang Yi

Yue Liu

Tao Tu

Xiao Tang

Mei Liu

Chengzhi Gao

Huan Liu

Liangyan Peng

Tingting He

Zhaojie Wang

Jiao Liu

Mingyang Hou

Jinping Wan

Lei Huang

Yun Tang

Gang Mei

Yanyan Zhang

Jvyuan Shui

Kai Wang

Maofen Chen

Cuifang Zhang

Xiaodan Wu

Liwei Liu

The present invention relates to the technical field of medicines, and relates to a polyethylene glycol conjugated drug, a preparation method therefor and the use thereof. In particular, the present invention relates to a polyethylene glycol conjugated drug as shown in formula I or a pharmaceutically acceptable salt thereof. The present invention also relates to a method for preparing the polyethylene glycol conjugated drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugated drug or the pharmaceutically acceptable salt thereof, and the use thereof in the preparation of a drug.

Polyethylene glycol conjugate drug, and preparation method therefor and use thereof

The present invention relates to a polyethylene glycol conjugate medicament, a preparation method therefor and use thereof, and in particular relates to a polyethylene glycol conjugate medicament represented by formula (I) or a pharmaceutically acceptable salt thereof. The present invention also relates to a method for preparing the polyethylene glycol conjugate medicament or a pharmaceutically acceptable salt thereof, and an intermediate of the same, a pharmaceutical composition comprising the polyethylene glycol conjugate medicament or a pharmaceutically acceptable salt thereof, and use thereof in preparing a medicament.

Polyethylene glycol conjugate medicament, preparation method therefor and use thereof

Disclosed are an intermediate drug having synergistic anticancer activity and a polyethylene glycol-coupled synergistic anticancer drug, and a method preparing therefor and use thereof. The intermediate drug has the general structural formula of (I), and the polyethylene glycol-coupled synergistic anticancer drug has the general structural formula of (II). The drugs achieve the combined medication of various anticancer drugs and avoid the toxic reaction caused by the interaction among the drugs or by the pharmacokinetics of the drugs when taking various anticancer drugs, facilitate overcoming the multidrug resistance of cancers, have a synergistic effect, and can be used for preparing anticancer medicaments and for treating cancers.

Intermediate drug with synergistic anticancer activity and polyethylene glycol-coupled synergistic anticancer drug, and preparation method therefor and use thereof

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Chongqing, China

Dajun Li