Venus Medtech (hangzhou) Inc.

Sichuan University

Venus Medtech, Inc.

Dajun Kuang

Jincheng Yu

Hou-Sen Lim

Min Frank Zeng

Li Yang

Yunbing Wang

Jesse Jun Qi

Lai Nguyen

Gaocan Li

Yang Lei

Lo Pham

Nan Shao

Hou Sen Lim

Housen Lim

A method for preparing a pre-loadable biological heart valve capable of rapid rehydration includes performing a cross-linking treatment, wherein a biological valve is cross-linked by soaking in an aqueous glutaraldehyde solution; performing a hydrophilic treatment, wherein the biological valve is soaked in a solution containing a hydrophilic molecule and a condensing agent, to allow the hydrophilic molecule to be immobilized on the biological valve by chemical grafting; and performing a drying treatment, wherein the biological valve after the hydrophilic treatment and the cross-linking treatment is dried to obtain the pre-loadable biological heart valve capable of rapid rehydration.

Pre-loadable biological heart valve capable of rapid rehydration and preparation method thereof

A pre-loadable dried biological heart valve and a preparation method thereof. The preparation method includes: Step A: soaking a fresh animal pericardium in an aqueous solution of soluble elastin or glycosaminoglycan, and then subjecting the pericardium to a first cross-linking reaction in a mixed solution of carbodiimide or N-hydroxysuccinimide to allow the soluble elastin or glycosaminoglycan to bind to the pericardium via a chemical bond; and Step B: subjecting the pericardium after the first cross-linking to a second cross-linking reaction in an aqueous glutaraldehyde solution, and then drying the pericardium after the second cross-linking, to obtain the pre-loadable dried biological heart valve. The dried biological heart valve obtained by the above preparation method has good toughness, and is rapidly flattened out in a simulated folding and pressing test.

Pre-loadable dried biological heart valve and preparation method thereof

A stent device with skirt folds and a processing method thereof, a skirt folding method, and a heart valve. The stent device comprises a stent () and a flexible skirt (), the skirt () having an expanded state, in which the skirt is axially extended and surrounds the stent () before release thereof, and a folded state, in which the skirt is driven by the deformation caused when the stent () is released, collapses and folds axially along the released stent () so as to form an annular peripheral leakage-blocking portion. The peripheral leakage prevention technology enables an interventional stent to fit to the inner wall of a vessel more snugly, such that the stent does not easily move and is more stable, thereby being suitable for more people, reducing additional risks of surgery and preventing complications such as peripheral leakage and thrombus. The present disclosure can provide better blood dynamics, increase the crawling capability of endothelial cells of a host, reduce the probability of occurrence of endocarditis, and restore a normal blood supply functionality of vessels.

Stent device with skirt folds and processing method thereof, skirt folding method, and heart valve

An in-vitro biological valve calcification evaluation method, comprising the following steps: preparing calcification evaluation solution comprising glutaraldehyde solution, saline solution, borate buffer solution, reducing calcium ingredient solution and calcium-containing plasma solution, the reducing calcium ingredient solution comprising alcohol, alkaline solution, oil and its derivatives, and buffer solution; preheating the reducing calcium ingredient solution; conducting treatment with the glutaraldehyde solution prior to reducing calcium ingredient solution; conducting treatment with the reducing calcium ingredient solution; preserving the valve samples; conducting in-vitro calcification reaction with the calcium-containing plasma solution; and detecting calcium content by atomic absorption spectrum.

In-vitro biological valve calcification evaluation method and reducing calcium ingredient solution

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Hangzhou, China

Dajun Kuang