Fujisawa Pharmaceutical Company, Ltd.

Daizou Morino

Ikuo Ueda

Hiroshi Imanaka

Koichi Takimoto

Kazuyoshi Jomon

Heiichi Sakai

Junzi Hosoda

Benzhydrylpiperazinyl Thiazole compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, amino, or mono- or di- substituted amino, in which the substituent is selected from lower alkyl, acyl and di(lower)alkylaminomethylene,

Benzhydrylpiperozinyl thiazole derivatives and pharmaceutical

Production of antibiotic WS-3442 A, B, C, D and E, and their acyl derivatives thereof, the production of antibiotic WS-3442 A, B, C, D and E being a new method by culturing a new species of Streptomyces and their acyl derivatives of said antibiotics being prepared by acylating said antibiotics with an acylating agent. The acyl derivative of antibiotic WS-3442 A, B, C, D and E has antimicrobiological activity and is also useful for intermediate for preparing Cephalosporin derivatives having antimicrobiological activity.

Production of antibiotics WS-3442 A, B, C, D and E, and their acyl

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Hatsutoriyutakamachi, Japan

Daizou Morino