Sagami Chemical Research Center

Tosoh F-tech, Inc.

Mitsui Chemicals, Inc.

Tosoh Corporation

Takasago International Corporation

Nagoya University

Daisuke Uraguchi

Tetsu Yamakawa

Kenji Tokuhisa

Kyoko Yamamoto

Hideo Shimizu

Masahiro Terada

Takashi Ooi

Keiichi Sorimachi

A chiral tetraaminophosphonium salt represented by formula (1) and a method for producing chiral &#x3b2;-nitroalcohol comprising reacting an aldehyde or a ketone and a nitroalkane in the presence of the chiral tetraaminophosphonium salt represented by formula (1) and a base, or in the presence of a conjugated base of the chiral tetraaminophosphonium salt represented by formula (1): wherein Rto Rare independently a hydrogen atom or a monovalent hydrocarbon group; and, Rand Rare different groups or Rand Rare different groups.

Chiral tetraaminophosphonium salts, catalyst for asymmetric synthesis and method for producing chiral &#x3b2;-nitroalcohol

Provided is a reaction reagent for trifluoromethylation with high general versatility and good efficiency. The reaction reagent for trifluoromethylation contains an iron compound, trifluoromethyl iodide, a sulfoxide and a peroxide, and may further contain an acid. The iron compound is, for example, iron(II) sulfate, ammonium iron(II) sulfate, iron(II) tetrafluoroborate, ferrocene, bis(&#x3b7;-pentamethylcyclopentadienyl)iron or an iron powder; the sulfoxide is, for example, dimethyl sulfoxide; the peroxide is, for example, hydrogen peroxide or hydrogen peroxide-urea composite; and the acid is, for example, sulfuric acid, tetrafluoroboric acid or trifluoromethanesulfonic acid.

Reaction reagent for trifluoromethylation

A process for producing an amine which is characterized by reacting an imine with a nucleophilic compound (except a trialkylsilyl vinyl ether) in the presence of a phosphoric acid derivative represented by the formula (1): wherein Arepresents a spacer; Xand Xrepresent each independently a divalent nonmetal atom or a divalent nonmetal atomic group; and Yis oxygen or sulfur. The invention provides a process by which amines (particularly optically active amines) useful as intermediates of medicines, agricultural chemicals, or the like can be produced without special post-treatment in high yield at high optical purity; and phosphoric acid derivatives (particularly optically active phosphoric acid derivatives) useful in the production of the amines.

Process for production of amines

Nucleobases are perfluoroalkylated in a one step process with a perfluoroalkyl halide in the presence of a sulfoxide, a peroxide and an iron compound. Compounds so produced are useful as medicinal drugs, intermediates for medicinal drugs and agricultural chemicals.

Nucleobase having perfluoroalkyl group and process for producing the same

Growing community of inventors

Nagoya, Japan

Daisuke Uraguchi