Mitsui Chemicals, Inc.

Mitsui Toatsu Chemicals, Incorporated

Daisuke Ura

Hiroyuki Katsuta

Nobuhiro Fukuhara

Koichi Ebihara

Michihiko Miyamoto

Toshio Kitashima

Toshio Matsumoto

Tooru Miyahara

Kenichi Satoh

Hisato Kamekawa

Tadashi Hashimukai

Toshiyuki Kohno

Tatsuo Kaiho

Makoto Yanaka

Kenichi Sato

Disclosed is an improved process for producing nitroisourea derivatives which is necessary for producing nitroguanidine derivatives having an insecticidal activity. Specifically disclosed is a process for producing nitroisourea derivatives represented by the following general formula (3), which is characterized in that nitroisourea derivatives represented by the following general formula (1) and amines represented by the following general formula (2) or a salt thereof are reacted in the presence of a catalytic amount of a hydrogen carbonate, 

Process for producing nitroisourea derivatives

A method for reducing a sulfur-containing compound by hydrogenation using a noble metal catalyst which method is exemplified by an industrial method for producing a 2-alkyl-3-aminothiophene derivative with high economical efficiency by hydrogenating a 2-alkenyl-3-aminothiophene derivative using the noble metal catalyst. 2-Alkyl-3-aminothiophene derivatives are useful compounds in the fields of medicine and agriculture, and in particular, useful in bactericides for agriculture or gardening, or intermediates of the bactericides. The hydrogenation reaction temperature is controlled at 150&#xb0; C. to 300&#xb0; C. and the method allows the used noble metal catalyst to be recovered and reused.

Method for producing 2-alkyl-3-aminothiophene derivative

A process, as a substitute for hydrolysis, for preparing a nitroguanidine derivative represented by the following formula (2): ##STR1## wherein A represents a substituted or unsubstituted aromatic or non-aromatic hydrocarbon ring, a substituted or unsubstituted aromatic or non-aromatic heterocycle, a hydrogen atom or a substituted or unsubstituted alkyl, alkenyl or alkynyl group; and R.sub.2 represents a hydrogen atom, a substituted or unsubstituted C.sub.1-6 alkyl, alkenyl or alkynyl group, which comprises reacting a compound represented by the following formula (1): ##STR2## wherein R.sub.1 represents a substituted or unsubstituted, linear or cyclic C.sub.1-10 alkyl group and A and R.sub.2 have the same meanings as defined above, with ammonia, a primary amine or a secondary amine, or a salt thereof.

Preparation process of nitroguanidine derivatives

The invention relates to a process for preparing L-serine from glycine and formaldehyde in the presence of cells of a microorganism or a cell-treated product having a serine hydroxymethyl transferase activity by an enzymatic method.

Process for the preparation of L-serine by an enzymatic method

L-Phenylalanine is isolated in pure form from an aqueous solution thereof containing cinnamic acid by subjecting the aqueous solution to toluene extraction to extract cinnamic acid therefrom; separating the toluene phase; and then concentrating the aqueous phase, until crystals of L-phenylalanine form therein, while concurrently separating the crystalline L-phenylalanine from the liquid aqueous phase.

Method for purifying L-phenylalanine

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Fukuoka, Japan

Daisuke Ura