Banyu Pharmaceutical Co. Ltd

Daisuke Uemura

Masanori Okanishi

Seiichi Tanaka

Hiroyuki Suda

Katsuhisa Kojiri

Akira Okura

Kohtaro Funaishi

Toshihiro Yamamoto

Yoshimasa Hirata

Takeshi Watanabe

This invention relates to 12,13-dihydro-6H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione derivatives represented by the following general formula, pharmaceutically acceptable salts thereof, a method for preparation thereof and a use thereof: ##STR1## [wherein R.sup.1 denotes a monosaccharide group having 5 to 7 carbon atoms, and the hydroxyl groups of this monosaccharide group can be replaced by the same or different 1 to 3 groups selected from the group consisting of a hydrogen atom, lower alkyl group, lower alkylcarbonyloxy group and lower alkoxy group.]

Method for preparing antitumor substance BE-13793C derivatives

Antitumor substance BE-13793C derivatives

The present invention provides glycookadaic acid or salts thereof, processes for the preparation of such compounds, methods for treating and preventing cachexia and a side effect caused by TNF, and pharmaceutical compositions comprising such compounds as active components for treating and preventing cachexia and a side effect caused by TNF.

Glycookadaic acid, preparation thereof and use thereof

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Shizuoka, Japan

Daisuke Uemura