Nissan Motor Company Limited

Fujifilm Corporation

Daisuke Terada

Eiji Shiotani

Kiyokazu Sugiyama

Yoshitsugu Noshi

Akira Shimizu

Takafumi Watanabe

Yoshito Utsumi

Hirotaka Miwa

Kiyohisa Suzuki

Mitsuo Hayashi

Kazuaki Taniguchi

Yoshiaki Miyamoto

Hidenobu Matsuyama

Hirohisa Shibayama

Jun Inomata

Satoru Sakurai

Akiharu Tashiro

Kei Fujii

Makoto Ando

Kimio Nishimura

Kiyoshi Hasegawa

Masaru Takasaki

Atsushi Hirai

Hiyoku Nakata

Hiroaki Mochida

Takuya Matsumoto

Shinsuke Mizumoto

Jun Nakabayashi

Masami Tashiro

Kimihiko Sato

Ryuji Fukada

Yohei Kubo

Masatoshi Inoguchi

Koichi Kanai

Junichi Uchiyama

Takashi Iiya

Shuhei Osaka

Shinsuke Inuki

Takayuki Monchujo

Megumi Ookubo

Hiroshi Hatta

Shuji Adachi

Hidehiko Tanaka

Tatsuya Nitabaru

Toshiaki Tsujino

Shintarou Tanabe

Atsush Hirai

Kiyokazu Sugiyma

The present invention provides a method for evaluating a synthetic aptitude of a compound, a program for evaluating a synthetic aptitude of a compound, and a device for evaluating a synthetic aptitude of a compound, which evaluate a synthetic aptitude of a compound generated and/or modified on a computer. The present invention relates to a method for evaluating a synthetic aptitude of a compound, the method including a step of selecting a compound database storing a plurality of reference compounds, a step of deciding a structure of a compound to be evaluated for the synthetic aptitude, a step of extracting a reference atomic arrangement from a structure of the reference compound stored in the compound database and obtaining a reference appearance frequency of the reference atomic arrangement, a step of extracting an atomic arrangement from the structure of the compound and obtaining an appearance frequency of the atomic arrangement, and a step of evaluating the synthetic aptitude based on the number of bonds included in the atomic arrangement of the compound and the appearance frequency of the reference atomic arrangement corresponding to the atomic arrangement; a program to execute the method; and a device to execute the method.

Method for evaluating synthetic aptitude of compound, program for evaluating synthetic aptitude of compound, and device for evaluating synthetic aptitude of compound

Provided is a defect detection device capable of measuring the volume of surface defects. The defect detection device includes: an imaging device configured to image an image of an inspection object; a binarization processing unit configured to subject the image to first and second binarization processing by use of different first and second binarization thresholds, so as to calculate first and second sizes for an identical defect in the image; a ratio calculation unit configured to calculate a first ratio of the second size to the first size; and a depth determination unit configured to determine a depth of the defect depending on the first ratio.

Defect detection device and production system

A thermally sprayed coating is formed on an inner surface of a cylinder bore of a cylinder block by using a thermal spray gun. The thermal spray gun is reciprocated along an axial direction in the cylinder bore while being rotated, and injects melted droplets generated by melting a wire made of a ferrous material from a nozzle at its end. At this time, a moving speed of the thermal spray gun along the axial direction into the cylinder bore is made equal-to or larger-than a predetermined value, and the number of reciprocating cycles of the thermal spray gun along the axial direction into the cylinder bore is made equal-to or larger-than a predetermined value.

Method for manufacturing cylinder block and cylinder block

In a method for manufacturing a cylinder block provided with cylinder bores, the cylinder block is held by a clamp device, stress is generated in the cylinder block by a holding force of the clamp device to duplicate deformations of the cylinder bores after assembling hearing caps thereon, boring is carried out with the cylinder bores deformed in a condition where the stress is generated, and a thermally sprayed coating is formed, after the boring, on each inner surfaces of the cylinder bores deformed in the condition where the stress is generated. According to the method for manufacturing a cylinder block, superior cylindricity, after assembling the bearing caps, of the cylinder bores on each of which the thermally sprayed coating is formed can be brought, and workability degradation of finishing works (honing) for each inner surface of the cylinder bores (thermally sprayed coatings) can be restricted.

Method for manufacturing cylinder block

In a method for a finishing work of a spray-coated surface, an inner surface of a cylindrical hollow member is roughened by forming a helical groove thereon. A thermal spray coating is formed on the inner surface that is roughened, and a finishing work is carried out by cutting the thermal spray coating along a helix of the groove by use of a cutting tool. According to the method for a finishing work, a finishing work of a thermal spray coating with non-uniform hardness can be carried out efficiently.

Method for finishing work of spray-coated surface and working tool

There is provided a morpholine derivative represented by General Formula [1A] or a salt thereof  (In the formula, a ring A represents a ring represented by General Formula [I]; * represents a bonding position; Zrepresents CH or the like; Zrepresents CRor the like; Rrepresents a hydrogen atom or the like; Xrepresents CHRor the like; Rrepresents a hydrogen atom or the like; Xrepresents CHor the like; Rand Rare the same as or different from each other, and each of Rand Rrepresents a hydrogen atom or the like; R, R, and Rare the same as or different from each other, and each of R, R, and Rrepresents a hydrogen atom, NRR, or the like; and each of Rand Rrepresents a hydrogen atom, a Calkyl group which may have a substituent, or the like).

Morpholine derivative or salt thereof

A cylinder block manufacturing method including: machining an inner surface of a cylinder bore () of a cylinder block () into a first shape different from a target shape before a bearing cap () is attached to the cylinder block () so that the inner surface of the cylinder bore () is deformed into the target shape by attachment of the bearing cap () to the cylinder block (); and forming a thermal spray coating () on the inner surface of the cylinder bore () having the first shape.

Cylinder block manufacturing method and cylinder block

The object is to provide an Fms-like tyrosine kinase 3 (FLT3) inhibitor useful as a therapeutic agent for acute myeloid leukemia (AML). A novel nitrogen-containing heterocyclic compound represented by the general formula [1] or a salt thereof is provided. The compound or a salt thereof of the present invention can be used as an active ingredient of a pharmaceutical composition for a treatment of a disease or condition relating to FLT3, such as acute myeloid leukemia (AML) and acute promyelocytic leukemia (APL).

Nitrogen-containing heterocyclic compound or salt thereof

A cylindrical internal surface processing method comprises forming a cylinder bore, roughening an upper section of the bore, depositing coating onto the bore, and machining a lower section of the bore and the coating. The forming of the cylinder bore includes forming the upper and lower sections with the lower section being axially spaced from the upper section and having an axial length greater than zero. The roughening creates a roughened surface such that a radially innermost edge of the roughened surface has an internal diameter smaller than an internal diameter of the lower section. The coating is deposited to cover the upper section and at least a portion of the lower section. The machining forms a tapered portion and a cylindrical portion, a radially outermost edge of the cylindrical portion having an internal diameter larger than that of a radially outermost edge of the roughened surface.

Cylindrical internal surface processing method

A method for processing a cylinder block is disclosed, wherein a protrusion protruding toward a crankcase is provided at a crankcase-side edge of a cylinder bore and a sprayed coating is formed on an inner surface of the cylinder bore and an inner surface of the protrusion continuous with the inner surface of the cylinder bore. After forming the sprayed coating, at least part of the protrusion is removed together with the sprayed coating formed on the inner surface of the protrusion. Accordingly, even in the case of removing the edge portion of the cylinder bore on the crankcase side, a sufficient margin to be removed can be ensured while a reduction in size of the cylinder block is achieved.

Method for processing cylinder block, cylinder block and thermal-sprayed cylinder block

A sprayed film forming method and apparatus in which the thickness of the sprayed film in a predetermined region is increased so as to unify the entire thickness. A sprayed film is formed at a cylinder bore inner surface while a spraying gun is moved in an axial direction during rotation inside the bore. Air inside the bore is sucked out to prevent foreign material from being caught in the sprayed film. The flow rate inside the bore tends to become higher at an axial end on a suction side, resulting in a thinned region. The supply speed of a wire serving as a spraying material to the spraying gun or the number of sprays in this region is higher than those at other portions. The thickness at the axial end of the bore is made equal while suppressing an increase in working time and spraying material used.

Method of forming sprayed film on the inner surface of a bore

A honing method and honing control device suitable for the honing having a large processing area is provided. The honing control device includes a grinder and an expansion member for disposition in a processing hole of a workpiece. The amount of an expanding movement when the grinder contacts the inner surface of a gauge hole via the expansion member is stored as a target expansion amount by inserting a honing head into the gauge hole having the same size as a target processing diameter of a master gauge. Then, a honing of an inner surface of the processing hole is performed by inserting the honing head within a processing hole of a workpiece moving the grinder towards an outer side of a diametrical direction by the expansion member installed within the honing head to rotate the honing head. The honing is completed when the amount of the expanding movement of the grinder reaches a target expansion amount established by the master gauge.

Honing method and honing control device

Growing community of inventors

Yokohama, Japan

Daisuke Terada