Astellas Pharma Gmbh

Toyo Ink Mfg. Co., Ltd.

Daisuke Tanabe

Kouji Hattori

Minoru Sakurai

Kenichi Washizuka

Takanobu Araki

Susumu Toda

Shinji Ito

Shinichi Sato

Daisuke Yamashita

Takashi Kamikubo

Hiroyuki Moritomo

Keizo Sugasawa

Seiji Aida

Kaori Nakano

Takashi Sugane

Takafumi Shimizu

Yasuhiro Yonetoku

Kyoichi Maeno

Norio Asai

Takuya Makino

Naomi Hosogai

Hisashi Mihara

Masashi Imanishi

Shinya Fujimatsu

Kazuhiko Osoda

Tetsuya Sai

To provide a compound which can be used as an MCreceptor agonist. The present inventors have investigated MCreceptor agonists, and have found that a piperazine derivative has an action related to the agonists, thereby completing the present invention. That is, the piperazine derivative of the present invention has an MCreceptor agonistic action, and can be used as an agent for preventing or treating bladder and/or urinary tract diseases, in particular, underactive bladder, hypotonic bladder, acontractile bladder, detrusor underactivity, neurogenic bladder, urethral relaxation failure, detrusor-external urethral sphincter dyssynergia, and voiding dysfunctions in benign prostatic hyperplasia.

Piperazine derivative

The present invention relates to a compound of the formula [I]: wherein (a), in which &#x2014;Y&#x2014;, R, Rand RareReach as defined in the description, etc., Ris hydrogen, halogen, lower alkyl, hydroxy, etc., Ris hydrogen, lower alkyl or hydroxy(lower)alkyl, Ris hydrogen or an amino protective group,is hydrogen, lower alkyl, cyclo(lower)alkyl, lower R9 alkenyl, &#x2014;Z&#x2014;Ror (b), in which &#x2014;Z&#x2014; is &#x2014;0&#x2014;, &#x2014;S&#x2014;, R&#x2014;SO&#x2014; or &#x2014;SO&#x2014;, and each Ris independently hydrogen, lower alkyl, cyclo(lower)alkyl, etc., and Ris -D-E-R, in which -D- is &#x2014;CONHSO&#x2014; or &#x2014;S0NHCO&#x2014;, E is bond or lower alkylene, and Ris halogen, cyano, carboxy, etc., or a prodrug thereof or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of ulcer, overactive bladder, and the like. 

Aminoalcohol derivatives

The present invention relates to a compound formula[I]: wherein  The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.

The invention relates to a pigment dispersion comprising: a condensate of or a salt between a polyallylamine and a polyester having a free carboxylic acid or the salt; a pigment derivative represented by the following general formula (1); a pigment; and an organic solvent,(P&#x2212;X)[N(R, R, R, R)]&#x2003;&#x2003;general formula (1)

Pigment dispersion and use thereof

A pigment dispersing agent of the formula (1) capable of providing a printing ink or a coating composition excellent in fluidity and dispersion stability and a dry coating excellent in gloss, a pigment composition containing the same and a pigment dispersion containing the same,  wherein Xis &#x2014;NH&#x2014;, &#x2014;O&#x2014;, &#x2014;CONH&#x2014;, &#x2014;SONH&#x2014;, &#x2014;CHNH&#x2014;, &#x2014;CHNHCOCHNH&#x2014; or &#x2014;X&#x2014;Y&#x2014;X&#x2014;, Xand Xare &#x2014;NH&#x2014; or &#x2014;O&#x2014;, Xis &#x2014;CONH&#x2014;, &#x2014;SONH&#x2014;, &#x2014;CHNH&#x2014;, &#x2014;NHCO&#x2014; or &#x2014;NHSO&#x2014;, Y is an alkylene group, an alkenylene group or an arylene group, Z is &#x2014;SOM or &#x2014;COOM, Ris a heterocyclic ring residue or an aromatic ring residue, Q is &#x2014;O&#x2014;R, &#x2014;NH&#x2014;R, a halogen group, &#x2014;X&#x2014;Ror &#x2014;X&#x2014;Y-Z, Ris a hydrogen atom, an alkyl group or an alkenyl group, and M is one equivalent of a monovalent to trivalent cation.

Pigment dispersing agent, pigment composition containing the same and pigment dispersion containing the same

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Tokyo, Japan

Daisuke Tanabe