Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Daisuke Shinmyo

Toshihiko Kaneko

Koichi Ito

Noritaka Kitazawa

Nobuaki Sato

Nobuyuki Kurusu

Daiju Hasegawa

Toshiyuki Uemura

Keigo Tanaka

Hironori Ikuta

Koki Kawano

Teiji Kimura

Mamoru Takaishi

Masashi Ito

Takao Saeki

Takehiko Miyagawa

Hiroaki Hagiwara

Takashi Doko

Toshimi Okada

Takeo Sasaki

Yu Yoshida

Hironobu Hiyoshi

Mamoru Yanagimachi

Toru Watanabe

Nobuhisa Watanabe

Kazuki Miyazaki

Yuichi Suzuki

Hiroyuki Sugumi

Yoichi Iimura

Noboru Yamamoto

Seiji Yoshikawa

Shinji Hatakeyama

Tetsuhiro Niidome

Tetsuyuki Teramoto

Manami Kimura

Yoshihisa Kaneda

Yukie Yoshikawa

Disclosed is a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, which is effective as a therapeutic or prophylactic agent for a disease induced by A&#x3b2;, wherein Arrepresents an imidazolyl group which may be substituted with a C1-6 alkyl group, or the like; Arrepresents a phenyl group which may be substituted with a C1-6 alkoxy group, or the like; Xrepresents a double bond, or the like; and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, or the like.

Polycyclic compound

A compound represented by the formula [I]: or a pharmacologically acceptable salt or ester thereof, wherein Ring A represents a five-membered aromatic heterocyclic group or the like fused with a non-aromatic ring group, which may be substituted, Ring B represents a phenyl group or the like which may be substituted, X1 represents a single bond or the like, R1 and R2 each represent a C1-6 alkyl group or the like, m represents an integer of 0 to 3, and n represents an integer of 0 to 2, is effective as a therapeutic agent for a disease caused by A&#x3b2;. 

Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors

A compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Arrepresents an imidazolyl group or the like which may be substituted with a C1-6 alkyl group, Arrepresents a phenyl group or the like which may be substituted with a C1-6 alkoxy group, Xrepresents a double bond or the like and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, is effective as a therapeutic or prophylactic agent for a disease caused by A&#x3b2;.

Imidazoyl pyridine compounds and salts thereof

An excellent squalene synthase inhibitor is provided. Specifically, what is provided is a compound (I) represented by the following formula, a salt thereof or a hydrate of them. In formula (I), Rrepresents an optionally substituted vinyl group or an aromatic ring which may be substituted. Also, n is an integer of 0 to 2. Further, X, Y and Z are the same as or different from each other and each represents an optionally substituted carbon atom, or an optionally substituted nitrogen atom, sulfur atom or oxygen atom, and Y optionally represents a single bond, and when Y represents the single bond, the ring to which X, Y and Z belong is a 5-membered ring. Also in the formula, CyA represents a 5- to 14 membered non-aromatic cyclic amino group or non-aromatic cyclic amido group which may be substituted, and the non-aromatic cyclic amino group or the non-aromatic cyclic amido group optionally having an oxygen atom or a sulfur atom. Finally, W represents a chain 

N-aryl-substituted cyclic amine derivative and medicine containing the same as active ingredient

The present invention provides a novel compound having a superior calcium antagonism, in particular, a neuron-selective calcium antagonism. Namely, it provides a compound represented by the following formula, a salt thereof or a hydrate of them.In the formula, Ar indicates an optionally substituted 5- to 14-membered aromatic ring etc.; the ring A indicates any one ring selected from a piperazine, a homopiperazine, a piperidine and the like; the ring B indicates an optionally substituted Con hydrocarbon ring etc.; E indicates a single bond, a group represented by the formula &#x2014;CO&#x2014;, etc.; X indicates a single bond, an oxygen atom etc.; Rindicates a hydrogen atom, a halogen atom, a hydroxyl group etc.; and D, D, Wand Ware the same as or different from each other and each represents a single bond or an optionally substituted Calkylene chain.

Piperazine compound and pharmaceutical composition containing the compound

Quinuclidine compounds and drugs containing the same as the active ingredient

Growing community of inventors

Tsukuba, Japan

Daisuke Shinmyo