Sumitomo Chemical Company, Limited

Daisuke Sasayama

Masahide Tanaka

Takashi Miyamoto

Kiyoshi Sugi

Yoshihiro Kawada

Taketo Hayashi

A compound represented by the formula (1) having controlling effects on harmful organisms can be produced by cyclizing a compound represented by the formula (2) in the presence of an organic sulfonic acid and acetic anhydride in a solvent, while removing water and acetic acid to the outside of the system.

Method for producing benzoxazole compound

A compound represented by formula (4) is produced by a step A of reacting a compound represented by formula (2): wherein Rrepresents an ethyl group or the like, R represents a halogen atom or the like, n represents 0, 1, 2, or 3, and M represents potassium or the like, with thionyl chloride to obtain a compound represented by formula (1): a step B of reacting the compound represented by formula (1) with a compound represented by formula (5): wherein Arepresents a nitrogen atom or &#x2550;CH&#x2014;, Rrepresents a trifluoromethyl group or the like, and m represents 1 or 2, to produce a compound represented by formula (3): or an acid salt thereof; and a step C of reacting the compound represented by formula (3) or an acid salt thereof in the presence of acid at 100&#xb0; C. to 180&#xb0; C. to obtain the compound represented by formula (4): 

Method for producing fused heterocyclic compound

Disclosed is a method for production of an optically active biphenylalanine compound represented by the formula (2): (wherein, Ris a protective group of an amino group, and Rand Rare each independently a hydrogen atom, etc.)or a salt thereof and an optically active biphenylalanine ester compound represented by the formula (3): (wherein, Ris an alkyl group, etc.)wherein the method comprises hydrolyzing a biphenylalanine ester compound represented by the formula (1): with a protease produced by a microorganism belonging tosp. in the presence of at least one alkali selected from an alkali metal hydroxide and an alkaline earth metal hydroxide.

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Osaka, Japan

Daisuke Sasayama