Canon Kabushiki Kaisha

Daisuke Sasaguri

Atsushi Takahashi

Tatsuki Fukui

Kengo Kanazaki

Masato Minami

Satoshi Ogawa

Ryoji Fujiwara

Fumio Yamauchi

Fumiko Tomatsu

Takeshi Ichikawa

Satoshi Yuasa

Keigo Mizusawa

Tetsuya Yano

Takeo Tsukamoto

Yoshinori Tomida

Yuji Kasanuki

Kouichi Kato

Michiyo Nishimura

Shoshiro Saruta

Shigeki Matsutani

Kazushi Nomura

Mayuko Kishi

Hiroyuki Aoki

Shinzaburo Ito

To provide a compound having high T/B and a contrast agent for optical imaging. The compound has a molecular weight of a specific range, the compound in which two polyethylene glycols are bonded to a specific cyanine pigment through a linker. The present invention provides a compound which has a high T/B and which can be used as a contrast agent capable of imaging a tumor portion with high contrast.

Compound and contrast agent for optical imaging having the compound

The present invention provides contrast agents for photoacoustic imaging which exhibit high degrees of accumulation in tumor and low degrees of retention in the blood and can be administered into the blood. The contrast agents for photoacoustic imaging include a conjugate of a dye and a polyethyleneglycol represented by Formula (1), (5), (6), or (7) and an additive represented by Formula (301). 

Composition having dye and conjugate of polyethyleneglycol and additive and contrast agent for photoacoustic imaging having the same

There is provided a contrast agent for photoacoustic imaging, the contrast agent exhibiting high tumor accumulation and high photoacoustic signal intensity even when time has passed since administration. A contrast agent for photoacoustic imaging comprises a complex including albumin covalently bound to an organic dye that absorbs light in the near-infrared wavelength region.

Contrast agent for photoacoustic imaging

There is provided an ICG-loaded polymer nanoparticle that is dynamically stable, prevents the leakage of contained ICG and the resulting discoloration, and has a high molar absorbance coefficient. The particle contains a hydrophilic dye having a sulfonate group and a hydrophobic polymer, and the particle further contains at least one of a lipid having a positively charged region, a nicotinic acid derivative and a thiamine derivative.

Particle and contrast agent having the particle

The present invention provides a compound which exhibits a high degree of accumulation into a tumor even when some extent of time has passed after performing administration and which facilitates an increase in the intensity of photoacoustic signal produced by the tumor. A compound produced by bonding of a polyethylene glycol and a specific cyanine based compound.

Compound and photoacoustic imaging contrast medium containing the compound

A method for producing a contrast agent includes the reaction step of allowing a cyanine dye containing a naphthyl group and a carboxyl or carboxylate group to react with a polyethylene glycol containing an amino group in an organic solvent to form a conjugate, and the purification step of purifying the conjugate using an organic solvent.

Method for producing contrast agent

Provided is a particle which can stably hold a dye in itself even in an aqueous solution such as serum, in order to solve such a problem of a particle containing ICG, which has been conventionally used in a contrast agent or the like, that the ICG is a dye having a hydrophilic functional group and hence the ICG leaks out of the particle in an aqueous solution such as serum. More specifically, provided is a particle including a hydrophobic dye having a cyanine structure, in which the hydrophobic dye is represented by the following chemical formula (1). 

Particle containing hydrophobic dye having cyanine structure, and contrast agent containing the particle

An image display apparatus includes a rear plate provided with a plurality of electron-emitting devices, each electron-emitting device emitting electron; a face plate disposed opposite the plurality of electron-emitting devices and provided with a plurality of pixels of phosphor, each pixel of phosphor being irradiated with electrons emitted from corresponding ones of the electron-emitting devices to generate light; and a driver for scanning the plurality of electron-emitting devices for emitting electron from the plurality of electron-emitting devices. The phosphor has luminescence center of allowed transition type material, and the driver scans the plurality of electron-emitting devices so that maximum of charge density dosed in one pixel phosphor, during one scanning period, is equal to or larger than 3&#xd7;10C/cm.

Image display apparatus and method of driving the same

There is provided an electron-emitting device of a field emission type, with which the spot size of an electron beam is small, an electron emission area is large, highly efficient electron emission is possible with a low voltage, and the manufacturing process is easy. The electron-emitting device includes a layerwhich is electrically connected to a cathode electrode, and a plurality of particleswhich contains a material having a resistivity lower than that of a material constituting the layer, and is wherein a density of particlesin the layeris 1&#xd7;10/cmor more and 5&#xd7;10/cmor less.

Method for manufacturing electron-emitting device

Electron-emitting device and manufacturing method thereof

A flat panel image display device includes a rear plate including plural electron emission elements, a face plate disposed opposed to the rear plate, fluorescent members being disposed on a surface of the face plate opposed to the rear plate, and the fluorescent members being covered with a metal back film, and a voltage applying unit to apply an acceleration voltage of 8 kV to 15 kV between the rear plate and the face plate. In addition, the metal back film has a getter material, and a current luminance characteristic of the fluorescent member satisfies &#x3b3;&#x2267;0.9 if L=kl&#x3b3; , wherein L is luminance, l is an irradiation current, and k is a constant.

Flat panel image display device

An object of the present invention is to enhance a converging property of an electron beam in an electron-emitting device in which a cathode electrode, an insulating layer, and a gate electrode are laminated and a through hole is formed by partially removing the gate electrode so as to obtain an exposed portion of the cathode electrode. In such an,electron-emitting device in which the cathode electrode, the insulating layer, and the gate electrode are laminated and the through hole is formed by partially removing the gate electrode so as to obtain the exposed portion of the cathode electrode, only a central region of the electron-emitting layer on the cathode electrode is connected to the cathode electrode. With this structure, it becomes possible to generate an electron beam only from the central region of the electron-emitting layer connected to the cathode electrode and to realize an electron-emitting device having a small beam diameter and a high-definition image-forming apparatus.

Electron-emitting device with electron blocking layer, electron source, and image-forming apparatus

A film deposition apparatus for forming a film on a substrate includes a chamber capable of maintaining a reduced-pressure atmosphere. The chamber includes a control electrode, a substrate holder opposite to the control electrode, the substrate holder holding the substrate, and a filament for emitting electrons disposed between the substrate holder and the control electrode. The film deposition apparatus further includes a unit for controlling the potential applied to the control electrode to be lower than the potential applied to the filament and a unit for controlling the potential applied to the substrate to be higher than the potential applied to the filament.

Film deposition apparatus and film deposition method

Disclosed is an electron-emitting device, an electron source, and an image-forming apparatus that have uniform electron-emitting characteristics, emit electron beams whose diameters are small, have simple constructions, and are easy to be manufactured. The electron-emitting device comprising: a first electrode arranged on a surface of a substrate; an insulating layer arranged on the first electrode; a second electrode arranged on the insulating layer; and an electron-emitting film arranged on the second electrode, where the second electrode has two side surfaces that oppose each other in a direction parallel to the surface of the substrate, and the electron-emitting film is arranged so as to be shifted toward one of the two side surfaces.

Method of driving image-forming apparatus and apparatus thereof

An electron emitting apparatus that can realize a convergence of electron trajectories and an improved electron emission efficiency. The apparatus comprises a substrate having a first primary surface that is substantially planar, an electron emitting device comprising first and second electroconductive members disposed on the primary surface and at an interval from one another, and an anode electrode having a substantially planar surface opposite to the first primary surface. A voltage applying means of the apparatus applies a potential higher than a potential applied to the first electroconductive member to the second electroconductive member to irradiate electrons emitted from the electron emitting device onto the anode electrode.

Growing community of inventors

Yokohama, Japan

Daisuke Sasaguri