Daiichi Sankyo Company, Limited

Arqule, Inc.

Daisuke Nakai

Takahiro Yamaguchi

Mark Anthony Ashwell

Kozo Oda

Naoki Terasaka

Kazuhiko Tamaki

Takahiro Murai

Darin Kizer

Takanori Yasukochi

Masakazu Nakadai

The present invention relates to pyrroloquinolinyl-pyrrolidine-2,5-dione compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing pyrroloquinolinyl-pyrrolidine-2,5-dione compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.

Pyrroloquinolinyl-pyrrolidine-2,5-dione compositions and methods for preparing and using same

A superior LXR modulator is provided. A compound represented by the general formula (I): [wherein R: &#x2014;COR(wherein R: alkyl, optionally substituted alkoxy or optionally substituted amino); R: H, OH, alkoxy, optionally substituted amino, etc.; R: H, optionally substituted alkyl, cycloalkyl, optionally substituted alkoxy, optionally substituted amino, halogeno, etc.; Rand R: H, optionally substituted alkyl, halogeno, etc.; Rand R: H, alkyl; R: &#x2014;XR[wherein R: &#x2014;COR(wherein R: OH, optionally substituted alkoxy, optionally substituted amino, etc.), &#x2014;SOR(wherein R: optionally substituted alkyl, optionally substituted amino, etc.), tetrazol-5-yl, etc.; X: single bond, optionally substituted alkylene, etc.]; X: &#x2014;NH&#x2014;, &#x2014;O&#x2014;, &#x2014;S&#x2014;, etc.; Y: optionally substituted phenyl, optionally substituted 5- to 6-membered aromatic heterocyclyl; Y: optionally substituted aryl, optionally substituted heterocyclyl, etc.] and the like is provided.

Benzene compound having 2 or more substituents

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Tokyo, Japan

Daisuke Nakai