Sanwa Kagaku Kenkyusho Co., Ltd.

Ube Industries, Inc.

Daisuke Kurumazuka

Toshiyuki Miyazawa

Satoko Harada

Toru Izuchi

Morio Okabe

Tomio Kimura

Motohisa Shimizu

Yasunori Tsuzaki

Hiroki Nagano

Ryo Iwamura

Hiroyuki Setoguchi

Mitsuaki Takeuchi

Kaori Taniko

Hiroto Akaza

Yuka Kuno

Tatsuroh Kaneko

Yuuki Imura

Katsunori Kitamoto

Nobuyoshi Kasugai

Hiroyo Kataoka

Yasushi Ohsawa

Hiroki Fujieda

Keita Sakai

Naoki Takahashi

Izumi Gotoh

Yukiyasu Asano

Yurie Yamada

The object of the present invention is to provide a compound having an antagonistic action against &#x3bc;-opioid receptors, which causes less side effects and thus is highly safe. A compound represented by the general formula (I), or a pharmacologically acceptable salt thereof:   

3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purpose

A compound having a V2 receptor agonistic activity is provided. Providing a pharmaceutical composition which contains, as an active ingredient, a compound represented by general formula (I) described below: [Ris formula described below: (A is a lower alkylene group which may be substituted with lower alkyl group; Ris a hydrogen atom; Ris a hydroxyl group, an aromatic heterocyclic group which may be substituted with lower alkyl group, carbamoyl group); Ris a hydrogen atom or lower alkyl group; Ris lower alkyl group which may be substituted with 1-3 fluorine atoms, or halogen atom; Ris a five-membered aromatic monocyclic heterocyclic group, five-membered non-aromatic monocyclic heterocyclic group, (provided each heterocyclic groups contain at least one nitrogen atom and may be substituted with a lower alkyl group); and Ris a lower alkyl group, halogen atom], or pharmacologically acceptable salt thereof.

Benzoazepine derivative and medical use thereof

Growing community of inventors

Inabe, Japan

Daisuke Kurumazuka