Otsuka Pharmaceutical Company, Limited

Daisuke Kuribayashi

Tadashi Mukai

Yuso Tomohira

Minoru Kashimoto

Yoshikazu Oka

Masakazu Nagasawa

Tetsuroh Ichiba

Hajime Toguchi

Tetsuroh 59-15 Aza Sumiyoshikaitaku Ichiba

Disclosed is a method for stabilizing a solid pharmaceutical preparation containing a pharmacological substance and sodium lauryl sulfate, the method comprising incorporating into the preparation at least one member selected from the group consisting of neutral salts, basic salts and basic substances. The preparation containing sodium lauryl sulfate prepared by the method of the invention has superior performance, including high storage stability, suppression of discoloration and deterioration, and prevention of change in its properties, such as the dissolution rate of pharmacological substance from the preparation.

Method for stabilizing preparation

A coating dispersion soluble in the lower digestive tract which is prepared by blending a hydroxypropyl methylcellulose acetate succinate (HPMCAS) soluble at around pH 7 with a conventional plasticizer and an anion surfactant and further adding an acid, wherein the HPMCAS has an average particle size of 10 &#x3bc;m or less and is dispersed at a concentration of 2 to 20% by weight, and the acid is used in an amount of 1 to 10 parts by weight per 100 parts by weight of HPMCAS, and a sustained release coated preparation capable of releasing a medicament in the large intestine at the lower digestive tract, which is prepared by coating a medicament-containing solid preparation such as a granular core with the coating dispersion.

Coated preparation soluble in the lower digestive tract

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Kakogawa, Japan

Daisuke Kuribayashi