Astellas Pharma Gmbh

Daisuke Kaga

Hiroyuki Moritomo

Masanori Miura

Fukushi Hirayama

Takao Okuda

Ippei Sato

Shunichiro Hachiya

Susumu Watanuki

Yoh Terada

Kazuhiro Terai

Koji Kato

Ryushi Seo

Yuji Koga

Jun Takasaki

Issei Tsukamoto

Hiroyoshi Yamada

Yoshimasa Imamura

Shinobu Akuzawa

Hidetaka Kaku

Yumiko Moritani

Norio Seki

Kenji Negoro

Ken-Ichi Suzuki

Jiro Fujiyasu

Daisuke Sasuga

Mai Isomura

The purpose is to provide a compound which has an intestinal phosphate transporter (NPT-IIb) inhibitory action and is useful as an active ingredient of an agent for treating and/or preventing hyperphosphatemia. A tetrahydrobenzothiophene compound of the following formula (I) has NPT-IIb inhibitory action and can be used as an agent for treating and/or preventing hyperphosphatemia: 

Tetrahydrobenzothiophene compound

[Problem] To provide a compound that has an intestinal phosphate transporter (NPT-IIb) inhibitory action and is useful as an active ingredient of an agent for treating and/or preventing hyperphosphatemia. [Means for Solution] The present inventors conducted their studies on a compound that has an NPT-IIb inhibitory action and is useful as an active ingredient of an agent for treating and/or preventing hyperphosphatemia. As a result, they created an aminoalkyl-substituted N-thienylbenzamide derivative which has NPT-IIb inhibitory action, thereby completing the present invention. The aminoalkyl-substituted N-thienylbenzamide derivative of the present invention has an NPT-IIb inhibitory action and can be used as an agent for preventing and/or treating hyperphosphatemia.

Aminoalkyl-substituted N-thienylbenzamide derivative

[Problem] To provide a compound which may be used for the prevention and/or treatment of diseases in which 5-HTreceptor and 5-HTreceptor are concerned, particularly for the treatment of irritable bowel syndrome (IBS). [Means for Resolution] It was found that a pyrrole derivative characterized by the possession of a guanidinocarbonyl group or amido group as a substituent group at the 3-position, or a pharmaceutically acceptable salt thereof, has a strong antagonism for both of the 5-HTreceptor and 5-HTreceptor. In addition, the compound of the present invention having the antagonistic activity for both of the receptors showed a good pharmacological action in comparison with the case in which an antagonist selective for either one of the receptors was used alone. Based on the above, the compound of the present invention is useful for the prevention and/or treatment of diseases in which 5-HTreceptor and 5-HTreceptor are concerned, particularly for the treatment of irritable bowel syndrome (IBS).

Pyrrole derivative or salt thereof

Problem: To provide compounds which have an anticoagulation effect based on their ability to inhibit the activated blood coagulation factor X and are useful as coagulation inhibitors or agents for prevention or treatment for diseases caused by thrombi or emboli. Means for Solution: Benzene derivatives or their salts having a characteristic chemical structure with a phenol ring and a benzene ring bonding to each other via an amide bond, in which the phenol ring further bonds to a benzene ring or a heteroaryl ring via an amide bond. They have an excellent effect of inhibiting the activated blood coagulation factor X, and especially have an excellent oral activity.

Benzene derivative or salt thereof

It was found that a compound according to the following formula: or a pharmaceutically acceptable salt thereof, has a strong antagonism for both the 5-HTand 5-HTreceptors. In addition, the compound shows good pharmacological action as compared to antagonists selective for only one of these receptors. Based on the above, the compound of the present invention is useful for the prevention and/or treatment of diseases in which 5-HTreceptor and 5-HTreceptor are concerned, particularly for the treatment of irritable bowel syndrome (IBS).

Amide derivative or salt thereof

A platelet aggregation inhibitor comprising a quinolone derivative or a pharmaceutically acceptable salt thereof as an active ingredient, and a novel quinolone derivative or a pharmaceutically acceptable salt thereof useful as a platelet aggregation inhibitor.

Quinolone derivative or salt thereof

Growing community of inventors

Chuo-ku, Japan

Daisuke Kaga