Mitsubishi Tanabe Pharma Corporation

Daisuke Iijima

Taichi Takahashi

Hisayuki Takamatsu

Kenji Fukunaga

Masahiro Okuyama

Norimitsu Hayashi

Shuzo Takeda

Hideki Horiuchi

Kenji Usui

Akinori Umino

Nobuaki Fujimoto

Noriaki Itagaki

A method for treating or preventing a disease involving autotaxin including administering a carboxylic acid compound of formula (1) or a pharmacologically acceptable salt thereof to a patient in need thereof.

3, 5-disubstituted pyridine and 3, 5-disubstituted pyridazine derivatives and pharmaceutical use of same

Provided is a compound superior in an ATX inhibitory action and useful for the prophylaxis or treatment of diseases involving ATX. A carboxylic acid compound represented by the following formula (1) or a pharmacologically acceptable salt thereof: wherein each symbol is as defined in the SPECIFICATION.

Provided are a novel compound having a superior inhibitory action on KAT-II, a production method thereof, use thereof, and a pharmaceutical composition containing the aforementioned compound and the like. A compound represented by the formula (I) or a pharmacologically acceptable salt thereof. wherein each symbol is as defined in the DESCRIPTION.

Bicyclic heterocyclic compound

The present invention provides a novel bicyclic or tricyclic heterocyclic compound represented by the formula (I) wherein ring A is an optionally substituted aromatic group,

Bicyclic or tricyclic heterocyclic compound

Provided is a compound superior in an autotaxin inhibitory action and the like, effective as a prophylactic or therapeutic drug for diseases involving ATX. The present invention relates to a compound represented by the following formula (I): [wherein each symbol is as described in the DESCRIPTION], which has a superior autotaxin inhibitory action and is useful as a prophylactic or therapeutic drug for diseases involving ATX.

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Osaka, Japan

Daisuke Iijima