Hitachi High-tech Corporation

Hitachi-high-technologies Corporation

Hitachi High-tech Science Corporation

Roche Diagnostics Operations, Inc.

Daisuke Akieda

Nobuhiro Tsukada

Makoto Nogami

Shinya Ito

Kenichiro Nishiki

Yoshihiro Nagaoka

Hironori Kaji

Yusuke Yota

Kenji Hiraku

Kimihiko Ishii

Katsutoshi Shimizu

Ayano Otsubo

Hisao Inami

Sho Iwasa

Ayumi Nakaogami

Shuhei Yamamura

Izumi Ogata

Yuichiro Hashimoto

Yusuke Shimizu

Kenichiro Tokuo

Kisaburo Deguchi

Kunihiko Takao

Jun Maeda

Masaru Yamasaki

Masato Fukuda

Shinya Matsuoka

Iwao Suzuki

Masako Kawarai

Takayuki Sugime

Mitsuhiko Ueda

Naoya Yasuhara

Toyoaki Tanoue

Shoji Tomida

Provided is a technology for reducing the capacity of a liquid feeding pump and enabling liquid feeding with little pulsation. A liquid feeding pump according to the present disclosure is provided with: a first plunger pump having a first plunger; a second plunger pump having a second plunger and connected in series with the first plunger pump; a pressure sensor disposed downstream of the second plunger pump; and a control unit that accepts the input of a liquid discharge pressure measured by the pressure sensor and that controls the driving of the first plunger and the driving of the second plunger. The control unit calculates the rate of change in the pressure of the liquid on the basis of the past compression distances of the plunger for when the liquid was compressed by the first plunger pump and the pressure at the completion of compression, predicts the compression distance of the first plunger on the basis of the rate of change in pressure and the present discharge pressure, and determines the timing at which the compression performed by the first plunger will be completed on the basis of the predicted compression distance.

Liquid feeding pump and liquid feeding method

The present invention provides a technique that enables liquid feeding with small pulsation by reducing the volume of a liquid feeding pump. Disclosed is a liquid feeding pump comprising: a first plunger pump that has a first plunger; a second plunger pump that has a second plunger and is connected to the first plunger pump in series; a pressure sensor that is disposed on the downstream side of the second plunger pump; and a control unit that accepts an input of the discharge pressure of a liquid measured by the pressure sensor to control driving of the first plunger and driving of the second plunger, wherein when the first plunger pump compresses the liquid, the control unit drives the first plunger at a first speed, and then decreases the speed to a second speed slower than the first speed before the compression is completed, and wherein the control unit discharges the liquid from the second plunger pump by driving the second plunger in parallel with the driving of the first plunger.

Tests of channels of a system as a whole can be easily performed without adding a complicated mechanism. A liquid feeding part includes a liquid feeding channel to feed a mobile phase, a drainage channel to release pressure in the liquid feeding channel, an analysis channel that discharges the mobile phase into the sample introduction part, and a channel switching valve that selectively connects the liquid feeding channel to one of the drainage channel and the analysis channel. The channel switching valve is configured to be able to provide a tight stopper state in which the liquid feeding channel is connected to neither the analysis channel nor the drainage channel.

Liquid chromatograph analyzer and method of controlling the same

A flowpath switch valve is configured for extended service life by spreading the region, of the sliding surfaces of a stator and a rotor, that is subject to wear over the entirety of the sliding surfaces. The stator has fixed stator flowpaths, and the rotor has rotor flowpaths. A flowpath switch valve, depending on the rotor rotation state, realizes connection patterns that include: a first connection pattern wherein a rotor flowpathconnects a fixed stator flowpathand a fixed stator flowpath; a second connection pattern wherein the rotor flowpathconnects the fixed stator flowpathand a fixed stator flowpath; a third connection pattern wherein a rotor flowpathconnects the fixed stator flowpathand the fixed stator flowpath; and a fourth connection pattern wherein the rotor flowpathconnects the fixed stator flowpathand the fixed stator flowpath

Flow passage switching valve, flow passage switching valve system, and liquid chromatograph

A liquid chromatograph has a long-life flow passage switching valve with reduced abrasion caused by sliding of flow passage end portions of a stator and flow passage end portions of a rotor seal. The flow passage switching valve includes: a stator; and a rotor seal connected with a rotor configured to rotate and slide on a circumference with respect to the stator. The stator has stator flow passages that open to the rotor seal. The rotor seal has a rotor seal flow passage for coupling two or more of the stator flow passages. A flow passage end portion that is positioned at a tip end in a sliding direction of the rotor seal flow passage is positioned in a direction opposite to the sliding direction of the stator flow passage end portion to be connected to the rotor seal flow passage, at least at the start of sliding.

Flow passage switching valve and liquid chromatograph having the same

The present invention relates to a liquid feeding apparatus capable of feeding a liquid with high accuracy. The liquid feeding apparatus includes a liquid feeder having a downstream side, a plunger, and a cylinder that is configured for aspirating and discharging a solvent when a plunger slides. The liquid feeding apparatus further includes a pressure sensor for the solvent to be discharged, a selector valve configured to switch between a plurality of solvents to be aspirated and discharged, and a controller configured to control the liquid feeder and the selector valve. The controller controls the selector valve in synchronization with an aspiration operation of the plunger so that a mixing ratio of the solvents changes, controls the plunger to cause the plunger to operate at first and second accelerations that are different from each other, and suppresses a fluctuation of the solvent to be aspirated by the plunger.

Liquid feeding apparatus and liquid feeding method

An analysis apparatus capable of adjusting holding time of each stream in a plurality of HPLC streams without adjusting a pipe length, and capable of determining degradation of a separation column, a liquid-delivery failure, or the like without removing a pipe from the apparatus is implemented. Air is suctioned from the shipperand injected into the verification flow pathsand, and holding time when a baseline of the detectorchanges is stored in the control unit. The air in the verification flow pathsandof the streamand the streamis measured, and holding time of the streamand holding time of the streamare compared to determine whether or not there is a difference of 1 second or more in the holding time. When the difference in holding time is 1 second or more, correction is performed. Holding time information of the same verification flow pathsandin the streamand the streamare compared with holding time information stored in the control unitand correction is performed when the difference in holding time is 1 second or more.

Analysis apparatus

An analysis apparatus column oven equipped with a plurality of columns is capable of efficiently performing heat conduction on column basis, recognizing a column cartridge that holds a column, and being easily exchanged on column basis. The column change mechanism includes a ferrule, a movable ferrule connector, a pipe, a fastener pull, a fastener fitting, a column cartridge presser, a slide guide, an RFID reader, a fixed wall, a column changer heat insulating member, a fixed bottom plate, a receiver, and a fixed fitting. A plurality of column cartridges can be installed in the heat block, and are in contact with the column heat block to control the temperature in the column cartridges. The column cartridge is fixed between left and right column change mechanisms, and when the fixed column cartridge is opened, the column change mechanism on the left side is moved leftward and opened.

Analysis apparatus column oven

The present invention makes it possible to realize an analysis apparatus having a plurality of liquid chromatographs capable of judging separation performance and the like at the right timing and improving analysis performance early. Analysis starts and a mixed sample is prepared by adding a non-retaining ingredient to a measurement object sample and is introduced into an analysis flow path (Sto S). The mixed sample is separated into components by a separation column, the components are outputted as chromatogram data by a detector, and the analysis finishes (Sto S). Retention time and peak information are acquired from the chromatogram outputted from the detector, whether or not a measurement result is within an allowable range is judged, and the process shifts to next analysis when the measurement result is within the allowable range (Sto S). An amount of transit time tof a non-retaining ingredient shifted from an allowable value is confirmed when separation performance is outside an allowable range at step Sand a separation column replacement instruction is outputted to an output unit when fluctuation of the transit time tis within an allowable range (S, S). A device maintenance instruction is outputted to the output unit when the fluctuation is outside the allowable range at step S(S).

Analysis apparatus having a plurality of liquid chromatographs and its analysis method

The analysis apparatus includes a standby section which is provided between a dispensing operation of an analysis item B′ prior to an analysis item C and the sample analysis channel introduction. The sample analysis channel introduction is arranged prior to a data collection section of an analysis item A. The operation is started earlier but after a sample dispensing operation section of the analysis item A. A sample dispensing operation section of the analysis item C can be started earlier and the analysis time of the analysis item C can be moved to immediately after a sample analysis operation section of the analysis item B′. The analysis item A in a second cycle can be started earlier by the early start time of the analysis item C in a first cycle. A total processing time Tc can be shorter than a total processing time Tb.

Analysis apparatus provided with a plurality of chromatographic apparatuses

A liquid feed pump which increases the liquid flow velocity in a stagnation area in the pressure chamber of a plunger pump, thereby improving the liquid replacement speed in the plunger pump. When the liquid in the liquid feed pump is replaced, a first plunger slides back and forth in the space between a lower limit point and an upper limit point, and the second plunger stops at least temporarily at a position near to the upper limit point or slides back and forth for a shorter distance than when the liquid feed pump usually feeds the liquid.

Liquid feed pump and liquid chromatography device

A minimum peak is determined from analysis results, a correction wavelength at which an S/N ratio of the minimum peak is greatest is determined, and the determined correction wavelength is used to execute correction of the minimum peak. A plurality of detector output value correction method are registered in a processor, correction method is selected from default correction method or from among a plurality of preset correction methods according to an object to perform correction.

Liquid chromatograph and method for correcting detector output value fluctuation of liquid chromatograph

An analysis method is achieved in which pressure variation resulting from sample injection or passage switching by an autosampler does not exert an influence on the control of a liquid transfer pump. The liquid chromatograph analysis method comprises the steps of: transferring two or more types of eluents while changing a mixing ratio between the eluents; adjusting an amount of the transferred liquid within a predetermined time in a passage for the eluent transferred; injecting a sample in the passage; supplying to a separation column the eluent into which the sample is injected; separating a target component in the sample; and detecting the target component thus separated. In this method, control is exercised so as to synchronize a liquid transfer cycle of the eluent with the sample injecting operation and to implement the sample injecting operation at a timing rather than the pressure obtaining time.

Liquid chromatograph apparatus and liquid chromatograph analysis method

A pump controller causes a first plunger pump and a second plunger pump connected in series or in parallel to perform intake and compression actions alternately at substantially constant cycles, sets a pressurizing chamber of one of the plunger pumps to a state of a higher pressure than the pressurizing chamber of the other plunger pump, and performs flow rate control by adjusting lift amounts of the first plunger and the second plunger. Thus, it is possible to provide a pump for liquid chromatograph, and a liquid chromatograph, which are capable of reducing pulsations even when an ejection flow rate is changed.

Growing community of inventors

Tokyo, Japan

Daisuke Akieda