Asahi Kasei Kogyo Kabushiki Kaisha

Daikichi Nishimura

Torao Ishida

Toshiaki Sugawara

Minoru Akiyama

Hiroshi Hayashi

Yoshio Sakurai

Shigeru Tsukagoshi

Nobuyoshi Emoto

Tadaaki Ooka

A N.sup.4 -alkoxycarbonylarabinofuranosylcytosine represented by the formula: ##STR1## wherein R is an aliphatic hydrocarbon group having 4 to 22 carbon atoms. These compounds are useful as anti-tumor agents.

N.sup.4 -Alkoxycarbonylarabinofuranosylcytosine

Compounds represented by formula (I) ##STR1## wherein one of Z.sub.1 ', Z.sub.2 ', Z.sub.3 ' and Z.sub.4 ' represents R, another one of Z.sub.1 ', Z.sub.2 ', Z.sub.3 ' and Z.sub.4 ' represents Z, and the remaining two moieties of Z.sub.1 ', Z.sub.2 ', Z.sub.3 ' and Z.sub.4 ' represents a hydrogen atom and/or a protective group, one of R and Z represents A.sub.1 and the other represents A.sub.2, A.sub.1 being an acyl group having 14 to 22 carbon atoms which does not contain a carboxylic group and A.sub.2 being an acyl group having 2 to 14 carbon atoms and having one carboxyl group, X represents a hydrogen atom or a halogen atom (hereinafter referred to as Compound Ia); a 2,2'-anhydro product of Compound Ia wherein Z.sub.2 ' represents a hydrogen atom (hereinafter referred to as Compound Ib); an arabinosylation product of Compound Ia (hereinafter referred to as Compound Ic); a deamination product of Compound Ia (hereinafter referred to as Compound Id); a 2'-deoxy product of Compound Id wherein Z.sub.2 ' represents a hydrogen atom (hereinafter referred to as Compound Ie); a salt of Compound Ia, Ib, Ic, or Id or Ie having an A.sub.2 group with a base (hereinafter referred to as Compound If); and a salt of Compound Ia, Ib or Ic wherein Z.sub.1 ' represents a hydrogen atom with an acid (hereinafter referred to as Compound Ih); and processes for preparing the same.

Diacylnucleosides and process for preparing the same

A compound represented by the formulae: ##STR1## wherein R.sub.1 and R.sub.2 are as defined hereinafter, useful as an anti-cancer or anti-tumor agent.

5-Fluorouracil derivatives

Growing community of inventors

Fuji, Japan

Daikichi Nishimura