Eisai R&d Management Co., Ltd.

Daiju Hasegawa

Toshihiko Kaneko

Koichi Ito

Noritaka Kitazawa

Nobuaki Sato

Daisuke Shinmyo

Toshiyuki Uemura

Koki Kawano

Teiji Kimura

Mamoru Takaishi

Takeo Sasaki

Takashi Doko

Hiroaki Hagiwara

Takehiko Miyagawa

Yu Yoshida

Toru Watanabe

Fumihiro Ozaki

Motohiro Soejima

Yoshihiko Norimine

Noboru Yamamoto

Eriko Doi

Tasuku Ishida

Kiyoaki Kobayashi

Nobuyuki Kurusu

Disclosed is a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, which is effective as a therapeutic or prophylactic agent for a disease induced by A&#x3b2;, wherein Arrepresents an imidazolyl group which may be substituted with a C1-6 alkyl group, or the like; Arrepresents a phenyl group which may be substituted with a C1-6 alkoxy group, or the like; Xrepresents a double bond, or the like; and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, or the like.

Polycyclic compound

A compound represented by the formula [I]: or a pharmacologically acceptable salt or ester thereof, wherein Ring A represents a five-membered aromatic heterocyclic group or the like fused with a non-aromatic ring group, which may be substituted, Ring B represents a phenyl group or the like which may be substituted, X1 represents a single bond or the like, R1 and R2 each represent a C1-6 alkyl group or the like, m represents an integer of 0 to 3, and n represents an integer of 0 to 2, is effective as a therapeutic agent for a disease caused by A&#x3b2;. 

Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors

Compounds represented by formula (I) and pharmaceutically acceptable salts thereof have excellent sodium channel inhibitory action and are useful as therapeutic agents and analgesics for various kinds of neuralgia, neuropathy, epilepsy, insomnia, premature ejaculation and the like. wherein Q represents ethylene, etc., R, Rand Rrepresent hydrogen, etc., Xrepresents Calkylene, etc., Xrepresents Calkylene, etc., Arepresents a 5- to 6-membered heterocyclic group, etc., and Arepresents Caryl, etc.

Bicycloamine derivatives

A compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Arrepresents an imidazolyl group or the like which may be substituted with a C1-6 alkyl group, Arrepresents a phenyl group or the like which may be substituted with a C1-6 alkoxy group, Xrepresents a double bond or the like and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, is effective as a therapeutic or prophylactic agent for a disease caused by A&#x3b2;.

Imidazoyl pyridine compounds and salts thereof

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Tsukuba, Japan

Daiju Hasegawa