Mitsui Chemicals, Inc.

Mitsui Toatsu Chemicals, Incorporated

Daiji Iwata

Akio Matsunaga

Hajime Edatsugi

Hiroshi Kohno

Yuki Nakajima

Nobuyuki Fukazawa

Hironori Komatsu

Kengo Otsuka

Osamu Yano

Tadashi Sudo

Wakao Sato

Shizuo Shimada

Yuki Mita

Shizio Shimada

Tuneji Suzuki

Yukichi Kawai

Kimiko Takezawa

Hiroshi Ohkouchi

Benzimidazole derivatives

Described herein is an anticancer agent, an antiviral agent or an antimicrobial agent which contains, as an active ingredient for acting on DNA, a compound presented by the following formula (1) or its pharmacologically acceptable salt: ##STR1##

Phenylbenzimidazole derivatives

Compounds of formula (1): ##STR1## wherein m is an integer 1, 2 or 3,

Sulfonium salts of pyrrolylbenzimidazoles

A monoclonal antibody which reacts with glycolipid asialo GM1 but not with any of glycolipids GM1 and GM2 can be produced by hybridoma cells obtained by fusing antibody-producing cells of a mammal immunized with the glycolipid asialo GM1 with myeloma cells.

Anti-asialo-GM1 monoclonal antibodies and method of use

Compounds having an activity to stimulate the carcinostatic effect of carcinostatic agents, which can be expressed by the following general formula (1): ##STR1## in which A is ##STR2## (in which R.sub.1, R.sub.2 and R.sub.3 are each independent and represent a hydrogen atom or a phenyl group) are made into fumarates so as to improve their oral absorbability and solubility in water without interfering with their effects.

Quinoline derivative fumarates

Disclosed is a novel anti-ganglioside GD.sub.1a monoclonal antibody (MZ) which is capable of recognizing ganglioside GD.sub.1a but is practically incapable of recognizing GalCer, LacCer, Gb.sub.3, Gb.sub.4, GA.sub.1, GA.sub.2, GM.sub.2, GM.sub.3, GD.sub.1b, GT.sub.1b, GQ.sub.1b, Fuc-GM.sub.1, nLc.sub.4 and sialosyl nLc.sub.4 ; MZ-producing cells; an MZ-containing reagent; and a method for the detection or quantification of GD.sub.1a using the reagent, e.g., to diagnose cancer, systematic lupus erythematosus and diseases resulting from organic injury of the nervous system.

Anti-ganglioside GD.sub.1 A monoclonal antibody MZ, MZ-producing cells

Growing community of inventors

Mobara, Japan

Daiji Iwata