Merck Patent Gmbh

Daigen Xu

Andrew Bender

Eike Staub

Ilhan Celik

Miriam Urban

Eileen Samy

Yin Wu

Richard Dana Caldwell

Lesley Liu-Bujalski

Sabine Raab

Albertina Pereira

Roland Grenningloh

Georgianna Higginbotham

Sabine Raab-Westphal

Georgianna Varrone

A method can treat a patient suffering from at least one of fibrosis and a fibrotic disorder. The method includes administering a therapeutically effective amount of an anti-αv integrin antibody DI17E6, or a biologically active variant or modification thereof, to the patient.

Anti-alpha-v integrin antibody for the treatment of fibrosis and/or fibrotic disorders

The invention relates to the prophylaxis and/or treatment of fibrosis and/or fibrotic diseases by means of antibodies. Above all, the invention relates to the administration of an anti-alpha-v integrin (receptor) antibody to patients suffering from fibrosis and/or fibrotic diseases, including but not limited to systemic sclerosis (SSc). More specifically, the instant invention relates to the treatment of fibrotic diseases of the skin, lung, heart, liver and/or kidney by means of said antibody. Even more specifically, the instant invention relates to the administration of a recombinant, de-immunized monoclonal antibody targeting &#x3b1;v-integrins patients suffering from systemic sclerosis, including, but not limited to systemic sclerosis of the skin, lung, heart and/or kidney by means of the anti-alpha-v integrin antibody DI17E6 and structural mutants or modifications thereof.

The present invention relates to BTK occupancy assays.

Assays for BTK inhibitors

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Westford, MA, United States of America

Daigen Xu