Irm LLC

Novartis Ag

Irm Llc, a Delware Limited Corporation

Dai Cheng

Shifeng Pan

Wenqi Gao

Dong Han

Yongqin Wan

Guobao Zhang

Jiqing Jiang

Yun Feng Xie

Yi Liu

Yang Yang

Nathanael Schiander Gray

Pamela Ann Albaugh

Donald Karanewsky

Yuan Mi

Badry Bursulaya

Yi Fan

Xia Wang

Xu Wu

Qihui Jin

Rajender Reddy Leleti

Lichun Shen

Donald S Karanewsky

The present invention relates to methods for modulating the Wnt signaling pathway using compounds of Formula (1), 

N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as Wnt signaling modulators

The present invention relates to compositions and methods for modulating the Wnt signaling pathway.

N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as WNT signaling modulators

The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).

Hedgehog pathway modulators

The present invention relates to compositions and methods for modulating the Wnt signaling pathway, using compounds having Formula (1) and (3): wherein A, B, Y and Z all represent rings, and R, R, Rare as defined herein. 

Substituted pyridines for modulating the WNT signaling pathway

The present invention relates to compounds of formulae 1 and 2 and methods for modulating the Wnt signaling pathway using these compounds, wherein A, A, B, Y and Z all represent rings. 

N-(hetero)aryl, 2-(hetero)aryl&#x2014;substituted acetamides for use as Wnt signaling modulators

The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or GIi gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I). 

Compounds and compositions as hedgehog pathway inhibitors

The invention provides a novel class of compounds of formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or dysregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb). 

Compounds and compositions as ITPKb inhibitors

The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.

Compounds and compositions as hedgehog pathway modulators

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-II, Rsk1, SGK, TrkA, TrkB and TrkC kinases.

Compounds and compositions as protein kinase inhibitors

The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I. 

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San Diego, CA, United States of America

Dai Cheng