Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation

Academia Sinica

Buddhist Tzu Chi Medical Foundation

Dah-Ching Ding

Kun-Chi Wu

Woei-Cherng Shyu

Hung Li

Shin-Zong Lin

Yu-Hsun Chang

Tang-Yuan Chu

Provided is a pharmaceutical composition including an effective amount of mesenchymal stem cell derived exosomes. Also provided is a use of the pharmaceutical composition for preserving cartilage tissue, promoting cartilage regeneration and repairing damaged joints, thereby preventing or treating joint disorders in a subject in need thereof.

Mesenchymal stem cell derived exosomes and method for preventing or treating a joint disorder by administering a composition comprising the same

The present invention provides a pharmaceutical composition comprising mesenchymal stem cells, a hyaluronan and a pharmaceutically acceptable carrier. The pharmaceutical composition is used for the treatment of the joint disease. The mesenchymal stem cells in the composition are at least one selected from the group consisting of infra-patellar fat pad stromal cells, bone marrow stem cells, Wharton's jelly stem cells and adipose derived stem cells. The concentration of the hyaluronan is in a range from 25% (v/v) to 75% (v/v). The present invention further provides a method for treating a joint disease, comprising a step of administrating a composition containing mesenchymal stem cells, a hyaluronan and a pharmaceutically acceptable carrier to an injured joint tissue of a subject.

Composition for treatment of joint disease and method thereof

An endometrial polyp stem cell is disclosed in the present invention. The endometrial polyp stem cell is isolated from an endometrial polyp tissue, expresses vimentin, CD13, CD29, CD44, and CD90, and has no expression of CD1q, CD3, CD34, and CD45.

Endometrial polyp stem cell

A cultured pluripotent animal cell that is CD13+, CD90+, and CD117&#x2212;. Also disclosed are methods for making the cell and methods of treating a brain tissue damage and increasing the expression level of a neuraltrophic factor in a subject.

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Hualien, Taiwan

Dah-Ching Ding