Schering Aktiengesellschaft

Virginia Commonwealth University

Triton Biosciences Inc.

Dagne L Florine

Robert W Akita

John S Ralston

Thomas J Smith

Methods are provided of preventing and treating chemotherapy or radiotherapy induced oral mucositis in a mammal by administering an effective dose of a growth factor, such as TGF-.alpha.. The growth factor may be used alone or in combination with other growth factors. Typically the effective dose is within the range of about 0.01-100 .mu.g/dose, administered 2-4 times daily.

Treatment and prevention of oral mucositis with growth factors

The present invention discloses synthetic peptides and antibodies raised thereto wherein the synthetic peptides represent important epitopic sites recognized by the 0.5 .alpha. antibody, a human monoclonal antibody which can neutralize HTLV-I. Also, the uses of these peptides or antibodies thereto either alone or in combination with peptides representing the epitopic site for the predominant antibodies found in HTLV-I env seropositive sera as diagnostics, therapeutics and vaccines are disclosed.

Growing community of inventors

Moraga, CA, United States of America

Dagne L Florine