Gruenenthal Gmbh

Endo Pharmaceuticals Inc.

Grunenthal Gmbh

Dagmar Lischke

Andreas Fischer

Dagmar Peters-Groth

Helmut Buschmann

Michael Gruss

Wolfgang Hell

Crystalline, anhydrous hydrochloride salts of 4,5&#x3b1;-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one (oxymorphone) are disclosed and three polymorphic forms of these salts are reported. The invention further relates to a method for the production of such salts, a pharmaceutical composition comprising an effective amount of such a salt as a medicament and for the treatment and/or prevention of pain.

Crystalline, anhydrous forms of oxymorphone hydrochloride

Crystalline, anhydrous hydrochloride salts of 4,5&#x3b1;-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one (oxymorphone) are disclosed and three polymorphic forms of these salts are reported. The invention further relates to a method for the production of such salts, a pharmaceutical composition comprising an effective amount of such a salt and such a salt as a medicament and for the treatment and/or prevention of pain.

This invention relates to solid crystalline forms of (1RS,3RS,6RS)-6-Dimethylaminomethyl-1-(3-methoxy-phenyl)cyclohexane-1,3-diol hydrochloride (1), methods of producing 1, methods of use of 1, use of 1 as analgesics and pharmaceutical compositions comprising 1.

Crystalline forms of (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexane-1,3-diol hydrochloride

A hitherto unknown crystalline form of (&#x2212;)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride, pharmaceutical compositions containing the new crystalline form, methods of producing the new crystalline form, and a related method of use including treatment of, e.g., pain and/or urinary incontinence.

Growing community of inventors

Inden-Altdorf, Germany

Dagmar Lischke