University of Pennsylvania

Other

Roth, Stephen

Daeyeon Lee

Kathleen J Stebe

David Aaron Issadore

Sagar Yadavali

Shu Yang

Fuquan Tu

Tiancheng Wang

Martin F Haase

Heon-Ho Jeong

Sarah D Hann

Giuseppe Di Vitantonio

Stephen A Roth

Bhavana Mohanraj

Chandra M Sehgal

Daniel A Hammer

Junhyong Kim

Yongwon Choi

Venkata Yelleswarapu

George R Dodge

Dengteng Ge

Robert L Mauck

Gaoxiang Wu

Kevin Vargo

Xu Zhang

Zhiwei Liao

Laura Bradley

Francesco Angile

Yang Lan

Junsang Doh

Yun-Ru Huang

Miju Kim

Syung Hun Han

Gang Duan

R Bharath Venkatesh

Adhesive hydrogels comprising a (co)polymer matrix, wherein the adhesive hydrogel comprises at least one rough surface as well as processes for preparing such hydrogels are disclosed.

Adhesive hydrogels and uses thereof

Methods of making robust bijels include dispersing metal oxide precursors and/or metal salts into at least one phase of a bijel and hydrolyzing and condensing the metal oxide precursors and/or metal salts in a sol-gel reaction to form sintered bridges between interfacially jammed surface-active nanoparticles. The methods can be used with any bijels, including those produced during solvent transfer-induced phase separation (STRIPS) methods and other methods. A robust bijel includes chemically sintered bridges between the interfacially jammed surface-active nanoparticles. Methods of making nanocatalyst-functionalized sintered bijels include adsorbing metal salts to a surface of sintered interfacially jammed nanoparticles of bijels, and reducing the metal precursors on the surface of the sintered nanoparticles. Nanocatalyst-functionalized sintered bijels include catalytically active metal or metal oxide nanocatalysts on a surface of the sintered interfacially jammed surface-active nanoparticles.

Robust bijels for interfacial catalysis and interphase separations

Provided is photoactivated selective release (or PHASR) of droplets from a microwell array enabled by a photoresponsive polymer layer integrated into the microfluidic device. This photoresponsive layer is placed in between a microwell array that traps a large number of droplets and a monolithic flow chamber that can be used for recovery. By using focused light, the photoresponsive layer can either be punctured or induced to create local heating to selectively release droplets. The type of photoacoustic dye and the physical properties of the photoresponsive layer can be engineered to induce either puncture of the membrane or pushing of droplets out of the microwells with low thermal impact on the droplets. This approach has broad application in the field of soft lithography-based microfluidic devices for various applications including photoresponsive valves as well as high throughput single cell sequencing.

Photoactivated selective release (PHASR) of droplets from microwell arrays

A method of making a bijel includes dispersing surface-active nanoparticles in a ternary liquid mixture. The ternary liquid mixture includes a hydrophilic liquid, a hydrophobic liquid, and a solvent. The ternary liquid mixture is contacted with water. A bijel includes a stable mixture of two immiscible liquids separated by an interfacial layer of colloidal particles. The bijel has temperature-independent stability, and the domain sizes are below one micrometer.

Bijels and methods of making the same

In one aspect of the invention, a microcapsule includes a film encapsulating a material. The film is formed by complexation of at least two mutually attractive components initially present in an aqueous dispersion comprising a continuous phase and a dispersed phase. The at least one first component is initially present in the continuous phase and the at least one second component is initially present in the dispersed phase. According to another aspect of the invention, provided is a process for forming microcapsules including the step of injecting a dispersed phase having at least a first component into a continuous phase having at least a second component, where the first component and the second component are mutually attractive, such that a film is formed by complexation of the first charged component and the second charged component.

Aqueous systems of at least two phases containing microcapsules and processes for manufacturing the same

Embodiments of the present invention relate to mechanically-activated microcapsules (MAMCs) for controlled drug-delivery, wherein the MAMCs release one or more active ingredients in response to mechanical stimuli in a subject's body. The MAMCs provide a platform for stimulating biological regeneration, biological repair, modifying disease, and/or controlling disease in mechanically-loaded musculoskeletal tissues.

Mechano-sensitive microcapsules for drug delivery

In one embodiment, a microfluidic device has a substrate that defines a first inlet for a continuous phase fluid, a second inlet for a dispersed phase fluid, and droplet generators that can produce micro-droplets from the continuous and dispersed phase fluids. The substrate defines (i) a plurality of delivery channels in fluid communication with the first and second inlets, each delivery channel having a first dimension along a first plane that is perpendicular to a transverse direction, and (ii) a plurality of trenches that extend from the delivery channels towards the droplet generators along the transverse direction. Each trench has a second dimension along a plane that is perpendicular to the transverse direction that is smaller than the first dimension. The substrate defines a plurality of vias that extend from the trenches to the droplet generators so as to fluidly connect the delivery channels with the droplet generators.

Silicon chip having multi-zone through silicon vias and method of manufacturing the same

Provided are Janus particles derived from natural starting materials, including starting materials that are plant-based and are not based on petrochemicals. Also provided are related compositions that include the disclosed particles, including emulsion compositions. Additionally provided are methods of synthesizing the disclosed Janus particles.

Scalable preparation of Janus particles with high naturality

Provided are systems and methods for inducing strain fields to give rise to controllable wrinkle patterns in a variety of substrates. Also provided are articles having persistent wrinkling patterns thereon.

Continuous manufacturing of surface wrinkle features

Provided are methods for forming polymer-infiltrated nanoparticle films by using capillary action to draw mobile molecular chains into the pores of a bed of nanoparticles. The chains can spread across the entire bed of nanoparticles. The disclosed methods also provide the formation of patterned polymer-infiltrated nanoparticle film compositions, as well as laterally graded compositions and compositions that feature a polymer gradient through the composition's thickness. Articles can be formed that include a plurality of polymer types infiltrated into the bed of nanoparticles.

Patterning polymer-filled nanoparticle films via leaching-enabled capillary rise infiltration (LeCaRI)

This disclosure demonstrates a new method to produce three dimensional multiphasic structures, including bijels, via vapor-induced phase separation (VIPS). In VIPS, the evaporation of the co-solvent from a ternary mixture of oil, water and ethanol, induces phase separation. Particles present in the mixture attach to the interface and arrest the phase separation between water and oil. VIPS enables, inter alia, the fabrication of films and coatings via spreading or spraying particle-laden suspension onto a surface without the need for an outer aqueous phase.

Three dimensional multiphasic structures via vaporization induced phase separation (VIPS)

A method of producing a nanocomposite film includes generating a bilayer film including at least a first layer of at least one nanoparticle and a second layer of at least one material and annealing the bilayer film. A uniform nanocomposite film includes a plurality of nanoparticles dispersed in a polymer matrix, wherein the plurality of nanoparticles form at least 60% by volume of the polymer nanocomposite film.

Nanocomposite films and methods for producing the same

A method for producing a click-active Janus particle includes combining seed particles with a monomer emulsion to obtain monomer-swollen seed particles; and polymerizing the monomer-swollen seed particles to obtain click-active Janus particles. A method for functionalizing a click-active Janus particle includes combining seed particles with a monomer emulsion to obtain monomer-swollen seed particles; polymerizing the monomer-swollen seed particles to obtain click-active Janus particles; and functionalizing the click-active Janus particles using one or more click chemistry reactions.

Click-active Janus particles and methods for producing and using the same

Microfluidic devices having a construct formed from perfluoropolyether and poly(ethylene glycol) diacrylate. The construct includes an inlet for receiving a continuous phase fluid, an inlet for receiving a dispersed phase fluid, and a plurality of channels extending through the construct. The plurality of channels are in fluid communication with both the inlet of the continuous phase fluid and the inlet of the dispersed phase fluid. The construct further includes a plurality of microdroplet generators configured to produce microdroplets, each of the microdroplet generators in fluid communication with the plurality of channels. Additionally, the construct includes an outlet formed in the construct and in fluid connection with the plurality of microdroplet generators.

Growing community of inventors

Wynnewood, PA, United States of America

Daeyeon Lee