University of Pittsburgh

Cornell University

Kraton Polymers LLC

Daewon Park

Yadong Wang

Thomas Richard Friberg

Carl Lesley Willis

Christopher Kemper Ober

Craig Jonathan Weinman

Dale L Handlin

Biodegradable triblock copolymer compositions are provided which are useful in tissue engineering and drug delivery. The copolymers are reverse thermal gels in that when heated from a lower temperature to a higher temperature, they gel. These gels are useful in drug delivery when complexed with an active agent. For example the compositions can be used for intraocular injection of active agents, such as anti-angiogenic agents for treatment of a maculopathy or retinitis.

Reverse thermal gels and uses therefor

The invention provides novel polymers, including triblock polymers, as well as methods of preparing the polymers, and compositions that include such polymers. The polymers can include at least three blocks, the first block that includes poly(styrene), the second block that includes a random arrangement of poly(ethylene) and poly(butylene), and a third block that includes functionalized poly(isoprene). Units of the functionalized poly(isoprene) block can include hydroxyl groups and one or more ether linked side chains comprising R, R, R, R, R, R, as defined herein, or a combination thereof. The polymers can be used to provide antifouling coatings, for example, for marine ship hulls.

Triblock polymers and polymer coatings

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Pittsburgh, PA, United States of America

Daewon Park