Entasis Therapeutics, Inc.

Daemian Dussault

Neil Bifulco

Bolin Geng

Hoan Huynh

Thomas Francois Durand-Reville

Janelle Comita-Prevoir

Brendan Chen

Satenig Guler

Hui Xiong

Liang Zhao

Shanta Bist

Ye Wu

Helen Mcguire

Helen McGuire

The present invention is directed to compounds which are beta-lacatamase inhibitors. The compounds and their pharmaceutically acceptable salts, are useful in combination with beta-lactam antibiotics, or alone, for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant organisms. The present invention includes compounds according to formula (Ia): or a pharmaceutically acceptable salt thereof, wherein the values of R, R, Rand Rare described herein.

&#x3b2;-lactamase inhibitor compounds

Beta-lactamase inhibitor compounds

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Lowell, MA, United States of America

Daemian Dussault