Procell Therapeutics Inc.

Dae Woong Jo

Jin Sook Kim

Thi Thuy Nga Do

Minh Tam Duong

Kyung Mi Park

Jung Hee Lim

Thi Lan Phuong Do

Jin Kyung Song

Jae Sun Ko

Yun Kyung Park

The present invention discloses novel macromolecule transduction domain (MTD) peptides which facilitate the traverse of a biologically active molecule across the cell membrane. Also disclosed are polynucleotides encoding the MTD peptides, methods of identifying the MTD peptides; methods of genetically engineering a biologically active molecule to have cell permeability by using the MTD peptides, methods of importing a biologically active molecule into a cell by using the MTD peptides, and uses thereof.

Macromolecule transduction domains and methods for identification and uses thereof

The present invention discloses cell permeable Nanog and Oct4 recombinant proteins that comprise a kaposi fibroblast growth factor 4 (kFGF4)-derived macromolecule transduction domain (MTD). Also disclosed are polynucleotides encoding the cell permeable Nanog and Oct4 recombinant proteins, a method of increasing self-renewal and suppressing differentiation of stem cells by treating the cells in combination with the cell permeable Nanog and Oct4 recombinant proteins, and the combined use of the cell permeable Nanog and Oct4 recombinant proteins for increasing self-renewal and suppressing differentiation of stem cells.

Combined use of cell permeable Nanog and Oct4 for increasing self-renewal and suppressing differentiation of stem cells

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Gwangju, South Korea

Dae Woong Jo