Korea Advanced Institute of Science and Technology

Korea Institute of Science and Technology

Dae-Sik Lim

Taehyun Kim

Hyewhon Rhim

Jin-Man Kim

Sang-Hee Lee

Ye Sun Han

Kwang-Pyo Lee

Hyun-Jung Oh

Joo-Hyeon Lee

Juhyun Choi

Sun Hye Jeong

Bon-Kyoung Koo

Sang-Phil Oh

Tae-Hong Yang

Young-Yun Kong

Tae-Shin Kim

Sunoh Kim

The present invention provides a method of manufacturing an animal model of non-alcoholic liver disease by using correlation among metabolic dysregulations through AKT regulation by Hippo signaling, and an animal model prepared by the method above, and a screening method of a therapeutic agent by using the animal model.

Animal model of non-alcoholic liver disease and composition of diagnosis, prevention or treatment for non-alcoholic liver disease

Mechanisms regulating cell proliferation stop and differentiation initiation during the development stage of mammalian embryo, and the proteins involved therein, are presented. Differentiation regulators, methods of regulating differentiation, transgenic organisms with loss of expression of the differentiation regulator, and methods of preparing the transgenic organisms, are provided.

Transgenic mouse defective in WW45 function and use in screening compounds for anti-tunour activity

There is provided a cell line that is prepared by transforming HEK293 cell with a human Kir2.1 gene using a retrovirus expression system, wherein the HEK293 expresses a stable &#x3b1;T-type calcium channel. The cell line responds sensitively to KCl and forms an appropriate level of the membrane voltage so that the cell signaling pathway may be investigated by the molecular biological and biochemical studies.

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Growing community of inventors

Daejeon, South Korea

Dae-Sik Lim