Il Dong Pharmaceutical Co., Ltd.

Ildong Pharm Co., Ltd.

Seoul National University

Mnh Bio Co., Ltd

Dae-Jung Kang

Jae-Hoon Kang

Seung-Hun Lee

Jong-Hyuk Im

Myung-Whan Suh

Tae-Yoon Kim

Hyun-Jung Jung

Gwangmin An

Hui Li

Yu-Jung Hwang

The present invention relates to controlled release formulations for treating hearing loss and a method for preparing the same, and more particularly, to controlled release formulations for treating hearing loss prepared by dispersing a steroidal anti-inflammatory agent encapsulated in low molecular weight hyaluronic acid in an aqueous solution of high molecular weight hyaluronic acid and a method for preparing the same.

Controlled-release formulation for hearing loss and preparation method therefor

The present invention relates to heat-killedconjugated to a polysaccharide polymer binder, a preparation method therefor and a use thereof. The heat-killedconjugated to a polysaccharide polymer binder of the present invention has an excellent therapeutic effect for atopic diseases, and particularly has high industrial applicability because membrane adhesion competitiveness, which is an advantage of existing lactic acid bacteria, is significantly improved, thereby exhibiting dermatitis preventing, alleviating and treating effects of the same level as steroid-based drugs.

RHT-3201 conjugated to polysaccharide polymer binder, and use thereof for prevention or treatment of atopic diseases

RHT-3201 (KCTC 10833BP) conjugated to polysaccharide polymer binder, and use thereof for prevention or treatment of atopic diseases

Provided is aID9103 strain having accession number KCTC11818BP, and a method of producing hyaluronic acid by culturing the strain to produce hyaluronic acid having an average molecular weight of 10,000,000 Da or more.

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The present invention relates to a buffer composition for promoting production of calcitriol or calcifediol, and a method for producing calcitriol or calcifediol using the same. More particularly, the present invention relates to a buffer composition for promoting production of calcitriol or calcifediol comprising a metallic compound, an organic solvent, cyclodextrin, tris(hydroxymethyl)aminomethane, sodium succinate, sodium chloride, magnesium chloride, and water, and a method for producing calcitriol or calcifediol using the same. In the method for producing calcitiriol or calcifediol, the production yield of calcitriol or calcifediol is high, and the bioconversion is carried out in an enzyme reaction system instead of in a microorganism culture system. Thus, it is not required to maintain a sterile state. Also, the separation/purification following the completion of a biocatalytic reaction can be carried out in a cleaner state than the microorganism culture method. Accordingly, there is an advantage in that a cost required for separation is low and the quality is improved. Furthermore, the buffer composition for promoting production of calcitriol or calcifediol can provide a high productivity of calcitriol or calcifediol.

Buffer composition for catalyzing the preparation of calcitriol or calcifediol and method for preparing calcitriol or calcifediol using same

Growing community of inventors

Gyeonggi-do, South Korea

Dae-Jung Kang