Mvrix Co., Ltd.

Sungkyunkwan University

Dae-Hyuk Kweon

Yong-Jun Kim

Baik Lin Seong

Suhyun Kim

Sukchan Lee

Yoon-Jin Bae

Yeon-Kyun Shin

Ki-Jun Jeong

Chang-Hwa Jung

Min-Ju Kim

Won-beom Park

Yoo-Soo Yang

Joon-Bum Park

Woo-Jae Chung

Wonbeom Park

Byoungjae Kong

Yun-Jeong Park

The present invention relates to a fusion protein in which a target protein and an Oct-1 protein-containing protein tag are linked, an expression structure comprising a nucleotide sequence encoding same, a recombinant vector including same, and a transformed cell including same.

Tag protein for increasing water solubility and heat stability of target protein, and fusion protein comprising same

The present invention relates to an antibody-bound lipid nanoparticle comprising an antibody conjugated with a membrane scaffold protein, and more specifically relates to an antibody-bound lipid nanoparticle which comprises a lipid, and an antibody conjugated with a membrane scaffold protein, and which can be easily produced and has an excellent specific targeting ability.

Antibody-bound lipid nanoparticle comprising antibody bound to membrane scaffold protein

The present invention relates to a method for producing botulinum toxin in various fragments to then be reassembled, for safely producing same. In the present invention, devised is a method in which: botulinum toxin is produced in fragments by cleaving light and heavy chains thereof into two or three pieces, respectively, and then combined as a full-length toxin, thereby allowing high complexity in production, due to toxicity, as well as low safety and economic feasibility, to be overcome; production of water-soluble botulinum toxin is enabled by using bacteria, thereby markedly shortening the production time as compared to existing production methods; and conjugation of the produced fragments with other proteins and nanoparticles is also enabled, thereby increasing the pharmaceutical extensibility of the toxin.

Method for safely producing botulinum neurotoxin

The present invention relates to a nanoperforator having a lipid-bilayer nanodisc and a membrane-structured protein surrounding the nanodisc and to a pharmaceutical composition having the nanoperforator as an active ingredient for preventing or treating viral infectious diseases. The use of the lipid-bilayer nanoperforator provided in the present invention can lead to the safe prevention or treatment of a disease caused by viral infection regardless of whether the virus is a variant or not, and thus the present invention can be widely used for the safe and effective treatment of viral infectious diseases.

Pharmaceutical composition comprising nanoperforator for preventing or treating viral infectious diseases

Disclosed is a composition for modulating the release of a neurotransmitter, which includes naturally extracted polyphenols as an active ingredient. The disclosed composition suppresses the formation of a SNARE complex, thereby modulating the release of a neurotransmitter, and thus can be used as a modulator for a reaction within a cell related to the SNARE complex. Such an inhibitor of the SNARE complex formation can be used as a composition for reducing wrinkles and relieving pain.

Polyphenol compounds with modulating neurotransmitter release

Growing community of inventors

Suwon-si, South Korea

Dae-Hyuk Kweon